Cruises to Panama Canal

Discover Panama Canal, starting from Colón, Panama

Panama Canal Cruises

Sailings that call at Panama Canal, earliest departure first.

346 Sailings Found
Panama City, Panama

12 Days One-Way from Panama City to Los Angeles

MSC Explora 3

Departs
April 22nd 2027
Duration
11 nights
From
$7,280
per person, double occupancy
Ports of call: +1 more port
Panama City, Panama

19 Days One-Way from Panama City to Vancouver

MSC Explora 3

Departs
April 22nd 2027
Duration
18 nights
From
$11,840
per person, double occupancy
Ports of call: +5 more ports
Colon, Panama

8 Days One-Way from Colon to San Juan

Grandeur Of The Seas

Departs
April 24th 2027
Duration
7 nights
From
$566
per person, double occupancy
Ports of call:

Why Book With Waterways Cruise?

Four decades of expertise, one dedicated advisor, and every detail handled, from your front door to the gangway and back.

Personal Service

Cruise Concierge

A dedicated advisor who learns your name, your travel style and your preferences, then stays with you from the first conversation to the day you return home. Not a call center. Never a stranger.

Tailor-Made

100% Custom‑Built

No cookie-cutter packages. Flights, hotels, transfers and shore days are designed from scratch around how you actually like to travel, then refined until the trip feels like yours.

Expertise

40+ Years in Travel

Founded by J. Richard, a four-decade veteran of the travel industry, and focused solely on premium river and ocean cruising. Decades of ship and itinerary knowledge go into every recommendation.

Security

Book With Total Confidence

A travel agency that is a proud member of Signature Travel Network, CLIA, ASTA and IATA.

Honolulu, United States

28 Days One-Way from Honolulu to Miami

Seabourn Quest

Departs
May 3rd 2027
Duration
27 nights
From
$10,599
per person, double occupancy
Ports of call: +5 more ports
Los Angeles, United States

20 Days One-Way from Los Angeles to Miami

Seabourn Quest

Departs
May 11th 2027
Duration
19 nights
From
$7,904
per person, double occupancy
Ports of call: +3 more ports
Los Angeles, United States

32 Days One-Way from Los Angeles to Lisbon

Seabourn Quest

Departs
May 11th 2027
Duration
31 nights
From
$13,499
per person, double occupancy
Ports of call: +5 more ports
San Diego, United States

36 Days One-Way from San Diego to London-Tilbury

Azamara Quest

Departs
May 24th 2027
Duration
35 nights
From
$12,659
per person, double occupancy
Ports of call: +13 more ports
San Diego, United States

18 Days One-Way from San Diego to Miami

Azamara Quest

Departs
May 24th 2027
Duration
17 nights
From
$4,939
per person, double occupancy
Ports of call: +3 more ports
Vancouver, Canada

33 Days One-Way from Vancouver to New York

Crystal Serenity

Departs
August 2nd 2027
Duration
32 nights
From
$13,870
per person, double occupancy
Ports of call: +16 more ports
San Diego, United States

12 Days One-Way from San Diego to Panama City

Crystal Serenity

Departs
August 9th 2027
Duration
11 nights
From
$5,030
per person, double occupancy
Ports of call: +2 more ports
San Diego, United States

26 Days One-Way from San Diego to New York

Crystal Serenity

Departs
August 9th 2027
Duration
25 nights
From
$10,670
per person, double occupancy
Ports of call: +11 more ports
Panama City, Panama

14 Days One-Way from Panama City to New York

Crystal Serenity

Departs
August 21st 2027
Duration
13 nights
From
$6,360
per person, double occupancy
Ports of call: +4 more ports
Nuuk, Greenland

81 Days One-Way from Nuuk to Ushuaia

Viking Octantis

Departs
September 9th 2027
Duration
80 nights
From
$77,999
per person, double occupancy
Ports of call: +27 more ports
Los Angeles, United States

19 Days One-Way from Los Angeles to Boston

Celebrity Summit

Departs
September 18th 2027
Duration
18 nights
From
$2,872
per person, double occupancy
Ports of call: +2 more ports
Vancouver, Canada

24 Days One-Way from Vancouver to New York

Coral Princess

Departs
September 22nd 2027
Duration
23 nights
From
$2,929
per person, double occupancy
Ports of call: +5 more ports
Los Angeles, United States

19 Days One-Way from Los Angeles to New York

Coral Princess

Departs
September 27th 2027
Duration
18 nights
From
$1,799
per person, double occupancy
Ports of call: +3 more ports
Seattle, United States

20 Days One-Way from Seattle to Miami

MSC Poesia

Departs
September 27th 2027
Duration
19 nights
From
$1,929
per person, double occupancy
Ports of call: +3 more ports
Los Angeles, United States

18 Days One-Way from Los Angeles to Miami

Norwegian Joy

Departs
September 30th 2027
Duration
17 nights
From
$2,319
per person, double occupancy
Ports of call: +4 more ports