Cruises to Panama Canal

Discover Panama Canal, starting from Colón, Panama

Explore Colón, Panama

Ports, excursions and things to do in Panama Canal.

Panama Canal Cruises

Sailings that call at Panama Canal, earliest departure first.

346 Sailings Found
Miami, United States

75 Days Miami, USA Round Trip

Azamara Journey

Departs
January 14th 2027
Duration
74 nights
From
$29,549
per person, double occupancy
Ports of call: +34 more ports
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Colon, Panama

8 Days One-Way from Colon to Puntarenas

Le Laperouse

Departs
January 15th 2027
Duration
7 nights
From
$6,230
per person, double occupancy
Ports of call:
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Panama City, Panama

10 Days One-Way from Panama City to Miami

Oceania Marina

Departs
January 16th 2027
Duration
9 nights
From
$3,195
per person, double occupancy
Ports of call: +3 more ports
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Why Book With Waterways Cruise?

Four decades of expertise, one dedicated advisor, and every detail handled, from your front door to the gangway and back.

Personal Service

Cruise Concierge

A dedicated advisor who learns your name, your travel style and your preferences, then stays with you from the first conversation to the day you return home. Not a call center. Never a stranger.

Tailor-Made

100% Custom‑Built

No cookie-cutter packages. Flights, hotels, transfers and shore days are designed from scratch around how you actually like to travel, then refined until the trip feels like yours.

Expertise

40+ Years in Travel

Founded by J. Richard, a four-decade veteran of the travel industry, and focused solely on premium river and ocean cruising. Decades of ship and itinerary knowledge go into every recommendation.

Security

Book With Total Confidence

A travel agency that is a proud member of Signature Travel Network, CLIA, ASTA and IATA.

Panama City, Panama

12 Days One-Way from Panama City to Oranjestad Aruba

Star Clipper

Departs
January 16th 2027
Duration
11 nights
From
$3,150
per person, double occupancy
Ports of call: +3 more ports
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Colon, Panama

5 Days One-Way from Colon to Panama City

National Geographic Quest

Departs
January 17th 2027
Duration
4 nights
From
$6,125
per person, double occupancy
Ports of call:
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New York, United States

17 Days One-Way from New York to Los Angeles

Queen Victoria

Departs
January 19th 2027
Duration
16 nights
From
$3,169
per person, double occupancy
Ports of call:
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New York, United States

37 Days One-Way from New York to Sydney

Queen Victoria

Departs
January 19th 2027
Duration
36 nights
From
$5,709
per person, double occupancy
Ports of call: +5 more ports
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Miami, United States

16 Days One-Way from Miami to Los Angeles

Seven Seas Prestige

Departs
January 20th 2027
Duration
15 nights
From
$36,498
per person, double occupancy
Ports of call: +2 more ports
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Panama City, Panama

5 Days One-Way from Panama City to Colon

National Geographic Quest

Departs
January 21st 2027
Duration
4 nights
From
$6,125
per person, double occupancy
Ports of call:
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Fort Lauderdale, United States

57 Days Fort Lauderdale, USA Round Trip

Queen Anne

Departs
January 22nd 2027
Duration
56 nights
From
$8,859
per person, double occupancy
Ports of call: +17 more ports
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Los Angeles, United States

17 Days One-Way from Los Angeles to Miami

Seven Seas Grandeur

Departs
January 24th 2027
Duration
16 nights
From
$33,098
per person, double occupancy
Ports of call: +3 more ports
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Panama City, Panama

28 Days One-Way from Panama City to Papeete

Seven Seas Splendor

Departs
January 26th 2027
Duration
27 nights
From
$50,798
per person, double occupancy
Ports of call: +7 more ports
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San Diego, United States

17 Days One-Way from San Diego to Fort Lauderdale

Island Princess

Departs
January 29th 2027
Duration
16 nights
From
$2,189
per person, double occupancy
Ports of call: +3 more ports
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Panama City, Panama

8 Days Panama City, Panama Round Trip

National Geographic Quest

Departs
January 29th 2027
Duration
7 nights
From
$8,000
per person, double occupancy
Ports of call:
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San Diego, United States

16 Days One-Way from San Diego to Miami

ms Zuiderdam

Departs
January 30th 2027
Duration
15 nights
From
$1,924
per person, double occupancy
Ports of call: +4 more ports
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Colon, Panama

9 Days One-Way from Colon to Puntarenas

Wind Star

Departs
January 31st 2027
Duration
8 nights
From
$6,730
per person, double occupancy
Ports of call: +2 more ports
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Colon, Panama

30 Days One-Way from Colon to Papeete

Wind Star

Departs
January 31st 2027
Duration
29 nights
From
$9,946
per person, double occupancy
Ports of call: +3 more ports
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Colon, Panama

36 Days One-Way from Colon to Papeete

Wind Star

Departs
January 31st 2027
Duration
35 nights
From
$15,182
per person, double occupancy
Ports of call: +8 more ports
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Cruise Lines Visiting Panama Canal