Cruises to Panama Canal

Discover Panama Canal, starting from Colón, Panama

Panama Canal Cruises

Sailings that call at Panama Canal, earliest departure first.

346 Sailings Found
Puntarenas, Costa Rica

8 Days One-Way from Puntarenas to Panama City

Star Legend

Departs
February 9th 2027
Duration
7 nights
From
$3,667
per person, double occupancy
Ports of call: +1 more port
Puntarenas, Costa Rica

14 Days One-Way from Puntarenas to Oranjestad Aruba

Star Legend

Departs
February 9th 2027
Duration
13 nights
From
$8,712
per person, double occupancy
Ports of call: +6 more ports
Los Angeles, United States

13 Days One-Way from Los Angeles to Panama City

Seven Seas Prestige

Departs
February 10th 2027
Duration
12 nights
From
$20,698
per person, double occupancy
Ports of call: +1 more port

Why Book With Waterways Cruise?

Four decades of expertise, one dedicated advisor, and every detail handled, from your front door to the gangway and back.

Personal Service

Cruise Concierge

A dedicated advisor who learns your name, your travel style and your preferences, then stays with you from the first conversation to the day you return home. Not a call center. Never a stranger.

Tailor-Made

100% Custom‑Built

No cookie-cutter packages. Flights, hotels, transfers and shore days are designed from scratch around how you actually like to travel, then refined until the trip feels like yours.

Expertise

40+ Years in Travel

Founded by J. Richard, a four-decade veteran of the travel industry, and focused solely on premium river and ocean cruising. Decades of ship and itinerary knowledge go into every recommendation.

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A travel agency that is a proud member of Signature Travel Network, CLIA, ASTA and IATA.

San Diego, United States

17 Days One-Way from San Diego to Miami

Norwegian Star

Departs
February 13th 2027
Duration
16 nights
From
$2,029
per person, double occupancy
Ports of call: +3 more ports
Panama City, Panama

15 Days One-Way from Panama City to Bridgetown

Star Legend

Departs
February 16th 2027
Duration
14 nights
Ports of call: +7 more ports
Panama City, Panama

7 Days One-Way from Panama City to Oranjestad Aruba

Star Legend

Departs
February 16th 2027
Duration
6 nights
From
$5,736
per person, double occupancy
Ports of call:
Valparaiso-Santiago, Chile

29 Days One-Way from Valparaiso-Santiago to San Francisco

ms Europa

Departs
February 17th 2027
Duration
28 nights
Ports of call: +9 more ports
Buenos Aires, Argentina

40 Days One-Way from Buenos Aires to Miami

Azamara Journey

Departs
February 18th 2027
Duration
39 nights
From
$16,979
per person, double occupancy
Ports of call: +16 more ports
Puntarenas, Costa Rica

8 Days One-Way from Puntarenas to Colon

Le Laperouse

Departs
February 19th 2027
Duration
7 nights
From
$5,550
per person, double occupancy
Ports of call:
Panama City, Panama

12 Days One-Way from Panama City to Miami

Seven Seas Prestige

Departs
February 22nd 2027
Duration
11 nights
From
$28,298
per person, double occupancy
Ports of call: +4 more ports
Miami, United States

14 Days One-Way from Miami to Panama City

Seven Seas Grandeur

Departs
February 23rd 2027
Duration
13 nights
From
$24,398
per person, double occupancy
Ports of call: +5 more ports
Buenos Aires, Argentina

42 Days One-Way from Buenos Aires to Fort Lauderdale

Viking Polaris

Departs
February 26th 2027
Duration
41 nights
From
$41,085
per person, double occupancy
Ports of call: +11 more ports
San Antonio, Chile

33 Days One-Way from San Antonio to Southampton

Queen Anne

Departs
March 1st 2027
Duration
32 nights
From
$4,769
per person, double occupancy
Ports of call: +5 more ports
Departs
March 1st 2027
Duration
18 nights
From
$3,099
per person, double occupancy
Ports of call: +2 more ports
San Antonio, Chile

36 Days One-Way from San Antonio to Hamburg

Queen Anne

Departs
March 1st 2027
Duration
35 nights
From
$5,429
per person, double occupancy
Ports of call: +7 more ports
Buenos Aires, Argentina

69 Days One-Way from Buenos Aires to Milwaukee Wi

Viking Octantis

Departs
March 2nd 2027
Duration
68 nights
Ports of call: +28 more ports
Valparaiso-Santiago, Chile

19 Days One-Way from Valparaiso-Santiago to Miami

Silver Nova

Departs
March 5th 2027
Duration
18 nights
From
$17,900
per person, double occupancy
Ports of call: +2 more ports
Panama City, Panama

23 Days Panama City, Panama Round Trip

Seven Seas Grandeur

Departs
March 9th 2027
Duration
22 nights
From
$49,298
per person, double occupancy
Ports of call: +3 more ports