Cruises to Panama Canal

Discover Panama Canal, starting from Colón, Panama

Panama Canal Cruises

Sailings that call at Panama Canal, earliest departure first.

346 Sailings Found
Fort Lauderdale, United States

22 Days One-Way from Fort Lauderdale to Seattle

ms Eurodam

Departs
April 3rd 2027
Duration
21 nights
From
$2,199
per person, double occupancy
Ports of call: +5 more ports
San Francisco, United States

25 Days One-Way from San Francisco to Miami

ms Europa

Departs
April 3rd 2027
Duration
24 nights
Ports of call: +7 more ports
Fort Lauderdale, United States

17 Days One-Way from Fort Lauderdale to Los Angeles

Crown Princess

Departs
April 4th 2027
Duration
16 nights
From
$1,299
per person, double occupancy
Ports of call: +3 more ports

Why Book With Waterways Cruise?

Four decades of expertise, one dedicated advisor, and every detail handled, from your front door to the gangway and back.

Personal Service

Cruise Concierge

A dedicated advisor who learns your name, your travel style and your preferences, then stays with you from the first conversation to the day you return home. Not a call center. Never a stranger.

Tailor-Made

100% Custom‑Built

No cookie-cutter packages. Flights, hotels, transfers and shore days are designed from scratch around how you actually like to travel, then refined until the trip feels like yours.

Expertise

40+ Years in Travel

Founded by J. Richard, a four-decade veteran of the travel industry, and focused solely on premium river and ocean cruising. Decades of ship and itinerary knowledge go into every recommendation.

Security

Book With Total Confidence

A travel agency that is a proud member of Signature Travel Network, CLIA, ASTA and IATA.

San Juan, Puerto Rico

17 Days One-Way from San Juan to Panama City

MSC Explora 3

Departs
April 5th 2027
Duration
16 nights
From
$11,175
per person, double occupancy
Ports of call: +7 more ports
Los Angeles, United States

31 Days One-Way from Los Angeles to Marseille

MSC Magnifica

Departs
April 7th 2027
Duration
30 nights
From
$12,999
per person, double occupancy
Ports of call: +8 more ports
Departs
April 8th 2027
Duration
10 nights
From
$7,420
per person, double occupancy
Ports of call: +4 more ports
Miami, United States

19 Days One-Way from Miami to Seattle

MSC Poesia

Departs
April 8th 2027
Duration
18 nights
From
$1,068
per person, double occupancy
Ports of call: +3 more ports
Miami, United States

26 Days One-Way from Miami to Seattle

MSC Poesia

Departs
April 8th 2027
Duration
25 nights
From
$2,696
per person, double occupancy
Ports of call: +8 more ports
New York, United States

23 Days One-Way from New York to Seattle

Norwegian Bliss

Departs
April 9th 2027
Duration
22 nights
From
$2,539
per person, double occupancy
Ports of call: +6 more ports
New York, United States

20 Days One-Way from New York to San Francisco

Norwegian Bliss

Departs
April 9th 2027
Duration
19 nights
From
$2,339
per person, double occupancy
Ports of call: +4 more ports
Fort Lauderdale, United States

18 Days One-Way from Fort Lauderdale to San Diego

ms Nieuw Amsterdam

Departs
April 11th 2027
Duration
17 nights
From
$1,994
per person, double occupancy
Ports of call: +3 more ports
Fort Lauderdale, United States

22 Days One-Way from Fort Lauderdale to Vancouver

ms Nieuw Amsterdam

Departs
April 11th 2027
Duration
21 nights
From
$2,334
per person, double occupancy
Ports of call: +5 more ports
Miami, United States

10 Days One-Way from Miami to Panama City

MSC Explora 3

Departs
April 12th 2027
Duration
9 nights
From
$7,860
per person, double occupancy
Ports of call: +2 more ports
Miami, United States

22 Days One-Way from Miami to Los Angeles

MSC Explora 3

Departs
April 12th 2027
Duration
21 nights
From
$14,240
per person, double occupancy
Ports of call: +8 more ports
Brisbane, Australia

46 Days One-Way from Brisbane to Miami

Seabourn Quest

Departs
April 15th 2027
Duration
45 nights
From
$18,699
per person, double occupancy
Ports of call: +13 more ports
Tampa, United States

16 Days One-Way from Tampa to Los Angeles

Celebrity Summit

Departs
April 18th 2027
Duration
15 nights
From
$3,147
per person, double occupancy
Ports of call: +2 more ports
Fort Lauderdale, United States

24 Days One-Way from Fort Lauderdale to Vancouver

Island Princess

Departs
April 19th 2027
Duration
23 nights
From
$2,150
per person, double occupancy
Ports of call: +8 more ports
Miami, United States

16 Days One-Way from Miami to Los Angeles

Norwegian Joy

Departs
April 21st 2027
Duration
15 nights
From
$1,929
per person, double occupancy
Ports of call: +2 more ports