Cruises to Panama Canal

Discover Panama Canal, starting from Colón, Panama

Panama Canal Cruises

Sailings that call at Panama Canal, earliest departure first.

346 Sailings Found
Colon, Panama

8 Days One-Way from Colon to Puntarenas

Star Legend

Departs
January 5th 2027
Duration
7 nights
From
$3,018
per person, double occupancy
Ports of call: +1 more port
Puntarenas, Costa Rica

11 Days One-Way from Puntarenas to Colon

Le Laperouse

Departs
January 5th 2027
Duration
10 nights
From
$9,370
per person, double occupancy
Ports of call:
Miami, United States

12 Days One-Way from Miami to Callao-Lima

Seabourn Quest

Departs
January 5th 2027
Duration
11 nights
From
$4,929
per person, double occupancy
Ports of call:

Why Book With Waterways Cruise?

Four decades of expertise, one dedicated advisor, and every detail handled, from your front door to the gangway and back.

Personal Service

Cruise Concierge

A dedicated advisor who learns your name, your travel style and your preferences, then stays with you from the first conversation to the day you return home. Not a call center. Never a stranger.

Tailor-Made

100% Custom‑Built

No cookie-cutter packages. Flights, hotels, transfers and shore days are designed from scratch around how you actually like to travel, then refined until the trip feels like yours.

Expertise

40+ Years in Travel

Founded by J. Richard, a four-decade veteran of the travel industry, and focused solely on premium river and ocean cruising. Decades of ship and itinerary knowledge go into every recommendation.

Security

Book With Total Confidence

A travel agency that is a proud member of Signature Travel Network, CLIA, ASTA and IATA.

Miami, United States

35 Days One-Way from Miami to Papeete

Seabourn Quest

Departs
January 5th 2027
Duration
34 nights
From
$15,809
per person, double occupancy
Ports of call: +7 more ports
Miami, United States

64 Days One-Way from Miami to Sydney

Seabourn Quest

Departs
January 5th 2027
Duration
63 nights
From
$31,024
per person, double occupancy
Ports of call: +24 more ports
Miami, United States

127 Days One-Way from Miami to Los Angeles

Seabourn Quest

Departs
January 5th 2027
Duration
126 nights
From
$75,399
per person, double occupancy
Ports of call: +52 more ports
Miami, United States

146 Days Miami, USA Round Trip

Seabourn Quest

Departs
January 5th 2027
Duration
145 nights
From
$102,099
per person, double occupancy
Ports of call: +58 more ports
Fort Lauderdale, United States

24 Days One-Way from Fort Lauderdale to Honolulu

Coral Princess

Departs
January 6th 2027
Duration
23 nights
Ports of call: +6 more ports
Fort Lauderdale, United States

16 Days One-Way from Fort Lauderdale to Los Angeles

Coral Princess

Departs
January 6th 2027
Duration
15 nights
From
$1,702
per person, double occupancy
Ports of call: +3 more ports
Miami, United States

16 Days One-Way from Miami to Los Angeles

Oceania Vista

Departs
January 6th 2027
Duration
15 nights
From
$11,549
per person, double occupancy
Ports of call: +3 more ports
Puntarenas, Costa Rica

8 Days One-Way from Puntarenas to Panama City

Star Clipper

Departs
January 9th 2027
Duration
7 nights
From
$2,010
per person, double occupancy
Ports of call: +1 more port
Southampton, United Kingdom

83 Days Southampton, United Kingdom Round Trip

Queen Anne

Departs
January 10th 2027
Duration
82 nights
From
$11,209
per person, double occupancy
Ports of call: +21 more ports
Southampton, United Kingdom

26 Days One-Way from Southampton to Los Angeles

Queen Victoria

Departs
January 10th 2027
Duration
25 nights
From
$2,799
per person, double occupancy
Ports of call: +1 more port
Miami, United States

14 Days One-Way from Miami to Panama City

Seven Seas Splendor

Departs
January 12th 2027
Duration
13 nights
From
$34,598
per person, double occupancy
Ports of call: +5 more ports
Miami, United States

42 Days One-Way from Miami to Papeete

Seven Seas Splendor

Departs
January 12th 2027
Duration
41 nights
From
$82,298
per person, double occupancy
Ports of call: +17 more ports
Puntarenas, Costa Rica

8 Days One-Way from Puntarenas to Colon

Star Legend

Departs
January 12th 2027
Duration
7 nights
From
$2,738
per person, double occupancy
Ports of call: +1 more port
Fort Lauderdale, United States

17 Days One-Way from Fort Lauderdale to San Diego

Island Princess

Departs
January 13th 2027
Duration
16 nights
From
$2,509
per person, double occupancy
Ports of call: +3 more ports
land tour, train/bus travel

9 Days One-Way from Land Tour to Panama City

National Geographic Quest

Departs
January 13th 2027
Duration
8 nights
From
$6,125
per person, double occupancy
Ports of call: