Cruises to Panama Canal

Discover Panama Canal, starting from Colón, Panama

Panama Canal Cruises

Sailings that call at Panama Canal, earliest departure first.

346 Sailings Found
Fort Lauderdale, United States

17 Days One-Way from Fort Lauderdale to San Antonio

ms Oosterdam

Departs
November 18th 2026
Duration
16 nights
From
$2,359
per person, double occupancy
Ports of call: +4 more ports
Fort Lauderdale, United States

31 Days One-Way from Fort Lauderdale to Buenos Aires

ms Oosterdam

Departs
November 18th 2026
Duration
30 nights
From
$4,989
per person, double occupancy
Ports of call: +13 more ports
Miami, United States

12 Days Miami, USA Round Trip

Norwegian Sun

Departs
November 18th 2026
Duration
11 nights
From
$1,519
per person, double occupancy
Ports of call: +2 more ports

Why Book With Waterways Cruise?

Four decades of expertise, one dedicated advisor, and every detail handled, from your front door to the gangway and back.

Personal Service

Cruise Concierge

A dedicated advisor who learns your name, your travel style and your preferences, then stays with you from the first conversation to the day you return home. Not a call center. Never a stranger.

Tailor-Made

100% Custom‑Built

No cookie-cutter packages. Flights, hotels, transfers and shore days are designed from scratch around how you actually like to travel, then refined until the trip feels like yours.

Expertise

40+ Years in Travel

Founded by J. Richard, a four-decade veteran of the travel industry, and focused solely on premium river and ocean cruising. Decades of ship and itinerary knowledge go into every recommendation.

Security

Book With Total Confidence

A travel agency that is a proud member of Signature Travel Network, CLIA, ASTA and IATA.

Departs
November 21st 2026
Duration
10 nights
From
$7,660
per person, double occupancy
Ports of call:
Miami, United States

12 Days Miami, USA Round Trip

MSC Poesia

Departs
November 22nd 2026
Duration
11 nights
From
$946
per person, double occupancy
Ports of call: +1 more port
Fort Lauderdale, United States

20 Days One-Way from Fort Lauderdale to Puntarenas

Crystal Serenity

Departs
November 23rd 2026
Duration
19 nights
Ports of call: +7 more ports
Fort Lauderdale, United States

29 Days One-Way from Fort Lauderdale to San Diego

Crystal Serenity

Departs
November 23rd 2026
Duration
28 nights
Ports of call: +13 more ports
Fort Lauderdale, United States

12 Days Fort Lauderdale, USA Round Trip

Celebrity Ascent

Departs
November 23rd 2026
Duration
11 nights
From
$1,351
per person, double occupancy
Ports of call: +1 more port
Fort Lauderdale, United States

15 Days Fort Lauderdale, USA Round Trip

Viking Mars

Departs
November 23rd 2026
Duration
14 nights
From
$4,999
per person, double occupancy
Ports of call: +2 more ports
Bridgetown, Barbados

19 Days One-Way from Bridgetown to Puntarenas

Wind Star

Departs
November 24th 2026
Duration
18 nights
Ports of call: +9 more ports
Bridgetown, Barbados

12 Days One-Way from Bridgetown to Colon

Wind Star

Departs
November 24th 2026
Duration
11 nights
From
$11,966
per person, double occupancy
Ports of call: +3 more ports
Puntarenas, Costa Rica

8 Days One-Way from Puntarenas to Colon

National Geographic Quest

Departs
November 29th 2026
Duration
7 nights
From
$6,228
per person, double occupancy
Ports of call: +3 more ports
Cartagena Colombia, Colombia

11 Days One-Way from Cartagena Colombia to Puntarenas

Crystal Serenity

Departs
December 2nd 2026
Duration
10 nights
From
$5,050
per person, double occupancy
Ports of call: +2 more ports
Los Angeles, United States

17 Days One-Way from Los Angeles to Fort Lauderdale

Crown Princess

Departs
December 3rd 2026
Duration
16 nights
From
$1,179
per person, double occupancy
Ports of call: +3 more ports
Bridgetown, Barbados

17 Days One-Way from Bridgetown to Panama City

Star Legend

Departs
December 4th 2026
Duration
16 nights
From
$6,014
per person, double occupancy
Ports of call: +7 more ports
Miami, United States

17 Days One-Way from Miami to San Diego

Norwegian Star

Departs
December 4th 2026
Duration
16 nights
From
$1,589
per person, double occupancy
Ports of call: +3 more ports
Bridgetown, Barbados

15 Days One-Way from Bridgetown to Panama City

Star Clipper

Departs
December 5th 2026
Duration
14 nights
From
$4,330
per person, double occupancy
Ports of call: +5 more ports
Colon, Panama

8 Days One-Way from Colon to Puntarenas

Wind Star

Departs
December 5th 2026
Duration
7 nights
From
$3,520
per person, double occupancy
Ports of call: +1 more port