Port Everglades, Florida Cruise from Port Everglades to San Antonio — 17 Days

16 nights · Port Everglades, Florida · Departs Fort Lauderdale (USA) · Visiting Grand Cayman Island, Panama Canal, Panama City, Manta, Salaverry-Trujillo, Callao-Lima, Pisco, Coquimbo, San Antonio · Aboard Holland America on the ms Oosterdam

Holland America logo
Cruise lineHolland America
Shipms Oosterdam
Duration16 nights
Port calls10
Departures1 sailings
From fare$2,359 per person
Year built2003
Guests2429
Cabins1012
Crew817
Length285 m
Beam32 m
Cruising speed22.0 kn
  1. Day 1

    Fort Lauderdale, USA

    Port Everglades puts Fort Lauderdale within easy reach of the city’s waterways, beaches and cultural attractions. A short drive brings you to Las Olas Boulevard, where galleries, restaurants and boutiques line a walkable stretch. Visit the Bonnet House Museum & Gardens for a glimpse of old Florida, or head west toward the Everglades. Fort Lauderdale’s broad Atlantic beaches offer an easy counterpoint to the city’s lively dining scene.

  2. Day 3

    Grand Cayman Island

    Grand Cayman pairs clear water with an easy blend of beach and town. Ships anchor offshore; tenders land in George Town, near duty-free shops, cafés and the Cayman Islands National Museum. Boat trips reach Stingray City, where visitors can encounter southern stingrays in shallow water. Beyond town, Seven Mile Beach is known for pale sand and turquoise water. Choose a beach transfer, an island tour or time in town; Grand Cayman makes a relaxed, rewarding call.

  3. Day 5

    Panama Canal, Panama

    Few journeys change your sense of scale like a passage through the Panama Canal. This 50-mile waterway links the Atlantic and Pacific, lifting ships through locks and across Gatun Lake. Watch the gates close, water rise, and a vast vessel move within inches of concrete walls. On deck, the engineering is the spectacle; beyond it, rainforest edges the route. Bring binoculars, and stay outside for the crossing.

  4. Day 5

    Panama City, Panama

    Balboa sits at the Pacific entrance to the Panama Canal, where ocean-going ships begin their passage between continents. From the port, Panama City’s skyline rises beyond the canal’s working waters. Visit Casco Viejo for restored colonial streets, independent cafés and views across the bay. Or follow the Amador Causeway toward the Biomuseo and sweeping views of ships awaiting transit. Balboa rewards travelers who look beyond the canal to a capital shaped by trade, history and the sea.

  5. Day 8

    Manta, Ecuador

    Manta is Ecuador’s principal Pacific port, where fresh tuna signals a city shaped by the sea. Visit the fish market, then explore the waterfront and discover how fishing built Manta’s identity. Nearby Montecristi is famed for Ecuadorian toquilla-straw hats, often mistakenly called Panama hats. Choose a Pacific beach escape, or linger over grilled seafood before returning to the ship.

  6. Day 10

    Salaverry-Trujillo, Peru

    Salaverry opens Peru’s northern coast, where ancient kingdoms and Spanish-era streets share the day. Trujillo, founded in 1534, lies about 14 kilometres inland and rewards a walk through its historic centre. Nearby, Chan Chan, the vast adobe capital of the Chimú, reveals a civilization that flourished before the Inca. At Huaca de la Luna, vivid painted reliefs bring the Moche world into view.

  7. Day 11

    Callao-Lima, Peru

    Callao is Peru’s working maritime gateway, but its appeal extends beyond the harbour. From here, Lima’s historic centre and museums are within reach. In Callao, explore the imposing Real Felipe Fortress, built to defend the port, then visit La Punta for Pacific views. Stay for ceviche and discover a city shaped by trade, naval history and the ocean.

  8. Day 13

    Pisco, Peru

    Pisco is Peru’s gateway to a stark coast where desert, ocean and wildlife meet. Nearby Paracas offers boat trips to the Ballestas Islands, where sea lions, Humboldt penguins and seabirds gather. The peninsula’s Paracas Candelabra, etched into a sandy hillside, is best seen from the water. In town, discover the grape brandy that shares Pisco’s name; the celebrated Nazca Lines lie farther inland to the south.

  9. Day 16

    Coquimbo, Chile

    Coquimbo opens onto a broad Pacific bay, where fishing boats share the water with visiting ships. Its working-port character feels distinct from neighbouring La Serena, whose colonial churches and long beaches lie just north. Climb to the Cross of the Third Millennium for sweeping coastal views, then seek fresh seafood along the waterfront. Inland, the Elqui Valley’s pisco distilleries and clear skies make an appealing day trip.

  10. Day 17

    San Antonio, Chile

    San Antonio is Chile’s largest commercial port, a working coastal city with a distinctly local rhythm. Its appeal extends beyond the docks: Santiago lies about 110 kilometres inland. Valparaíso is north, while the Casablanca Valley’s wineries offer a rewarding excursion nearby. Begin at the fish market and waterfront, or venture to Santiago, Valparaíso and Casablanca’s vineyards.

ms Oosterdam Cruises

Published September 29, 2026
Last updated October 3, 2026
Author: J. Richard


Cruise Disclosure

Good to know: Prices are quoted per person based on double occupancy and include all applicable taxes and fees. Availability and prices can change quickly, so please continue through the booking process to confirm the latest availability and pricing before you pay.

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