Greece Cruise from Piraeus to Barcelona — 22 Days

21 nights · Greece · Departs Piraeus-Athens (Greece) · Visiting Mykonos Island, Istanbul, Kusadasi, Kos Island, Rhodes Island, Katakolon, Sarande, Valletta, Messina, Naples, Civitavecchia-Rome, Ajaccio, Villefranche-sur-Mer, Barcelona · Aboard Holland America on the ms Oosterdam

Holland America logo
Cruise lineHolland America
Shipms Oosterdam
Duration21 nights
Port calls15
Departures1 sailings
From fare$3,794 per person
Year built2003
Guests2429
Cabins1012
Crew817
Length285 m
Beam32 m
Cruising speed22.0 kn
  1. Day 1

    Piraeus-Athens, Greece

    Piraeus is Athens’ working harbour, not a resort port—and that is its appeal. From here, the capital’s ancient landmarks are within reach, while the waterfront keeps its own busy, distinctly Greek character. Visit the Archaeological Museum of Piraeus, then linger over grilled fish in Mikrolimano, a small harbour lined with tavernas. Metro connections make central Athens straightforward. Or stay near the water and watch ferries depart for the islands.

  2. Day 2

    Mykonos Island, Greece

    Mykonos rewards an early start: whitewashed lanes, blue-domed churches and waterfront cafés are quieter before the cruise crowds arrive. In Little Venice, old captains’ houses lean over the Aegean, while the island’s windmills stand above the harbor. Beyond town, beaches range from lively Psarou to the broad sands of Elia. Take a short boat ride to Delos, where ancient sanctuaries and marble streets mark one of Greece’s great archaeological sites.

  3. Day 4

    Istanbul, Turkey

    Istanbul makes a compelling first impression: minarets rise above the Bosphorus, while ferries cross between Europe and Asia. On the historic peninsula, Hagia Sophia, the Blue Mosque and Topkapi Palace place centuries of empire within walking distance. Istanbul rewards curiosity beyond its landmarks. Browse the Grand Bazaar, linger over Turkish coffee, then take a ferry to the Asian shore. Allow time for traffic and queues; the city’s scale is part of the experience.

  4. Day 7

    Kusadasi, Turkey

    Kuşadası puts the Aegean within reach, with a lively waterfront and one of Turkey’s most celebrated ancient cities nearby. Ephesus lies about 20 kilometres inland, where marble avenues lead to the Library of Celsus and Great Theatre. Back in town, browse the bazaar, then follow the causeway to Pigeon Island and its historic fortress. The harbour-facing promenade offers an easy place to linger over the Aegean light.

  5. Day 8

    Kos Island, Greece

    Kos is one of the Dodecanese’s most accessible islands, and its port opens straight onto a walkable town. At the harbour entrance, the medieval Castle of Neratzia recalls the island’s strategic past. Nearby, the Plane Tree of Hippocrates evokes Kos’s medical heritage; the present tree, however, is not ancient. Make time for the Asklepieion, the island’s celebrated ancient healing sanctuary, set above town among terraces with broad views.

  6. Day 9

    Rhodes Island, Greece

    Rhodes pairs a fortified medieval capital with a sunlit Aegean coast. The UNESCO-listed Old Town stands just beyond the harbour, enclosed by formidable walls built by the Knights of St John. Walk its cobbled lanes to the Palace of the Grand Master, then pause over coffee in a shaded square. Beyond the city, beaches and whitewashed Lindos reward a longer outing; an ancient acropolis crowns the bay.

  7. Day 11

    Piraeus-Athens, Greece

    Piraeus is Athens’ working harbour, not a resort port—and that is its appeal. From here, the capital’s ancient landmarks are within reach, while the waterfront keeps its own busy, distinctly Greek character. Visit the Archaeological Museum of Piraeus, then linger over grilled fish in Mikrolimano, a small harbour lined with tavernas. Metro connections make central Athens straightforward. Or stay near the water and watch ferries depart for the islands.

  8. Day 12

    Katakolon, Greece

    Katakolon is a compact seaside port on the western Peloponnese, with cafés and shops lining its waterfront. Most visitors come for ancient Olympia, about 35 kilometres inland and readily reached by road. There, the sanctuary, archaeological museum and ancient stadium bring the story of the Olympic Games into focus. Back in Katakolon, allow time for a stroll along the harbour before returning to your ship.

  9. Day 13

    Sarande, Albania

    At Sarandë, the Ionian Sea glitters; Corfu lies across the water, and Albania’s southern coast begins here. Palm-lined promenades, small beaches and seafood restaurants make the waterfront an easy place to settle. Then head south to Butrint, a UNESCO-listed archaeological site amid lagoons and woodland. Inland, the Blue Eye spring rewards a longer excursion with strikingly clear water. Look up to Lëkurësi Castle for broad views over town, sea and island.

  10. Day 15

    Valletta, Malta

    Valletta makes a powerful first impression, its honey-coloured walls rising above Grand Harbour. Founded by the Knights of St John in 1566, Malta’s compact capital rewards exploration on foot. Enter St John’s Co-Cathedral for Caravaggio’s monumental paintings, then follow Republic Street to cafés, palaces and the Upper Barrakka Gardens. From the terraces, watch ferries cross the harbour and look towards the Three Cities. Allow time for steep lanes and quiet side streets.

  11. Day 16

    Messina, Italy

    Messina faces Calabria across the narrow Strait of Messina, with mainland Italy visible from its waterfront. At noon, figures move across the cathedral’s clock tower, a daily spectacle best seen from the square. Nearby, Montorsoli’s 16th-century Fountain of Orion rewards a closer look. Excursions reach Taormina and Mount Etna, but Messina’s compact center also merits an unhurried walk.

  12. Day 17

    Naples, Italy

    Naples puts its history within reach: the port opens onto a compact city framed by Mount Vesuvius and the bay. UNESCO-listed streets lead to churches, palaces and the everyday theatre of southern Italian life. At the National Archaeological Museum, mosaics and objects from Pompeii and Herculaneum bring the Roman world sharply into focus. Stay close for Neapolitan pizza, or use Naples as a springboard to Pompeii, Herculaneum and Capri.

  13. Day 18

    Civitavecchia-Rome, Italy

    Your ship docks at Civitavecchia, Rome’s seaport, about 50 miles northwest of the capital. Rome’s great monuments are within reach, but the port town rewards a closer look. Walk the waterfront to Forte Michelangelo, a 16th-century fortress begun under Pope Julius II; explore the old streets and market. Prefer a quieter day? The town’s seafront and nearby beaches offer an easy change of pace. Choose Rome for art and antiquity, or Civitavecchia for coastal life beyond the terminal.

  14. Day 19

    Ajaccio, France

    Ajaccio brings Corsica’s character within easy reach of the quay. France’s island capital pairs a sheltered gulf with pastel façades, a lively old town and mountain ridges above the harbor. Napoleon Bonaparte was born here in 1769; his birthplace is now a museum. From Place Foch, browse the market before following narrow lanes to the cathedral and waterfront cafés. Allow time for a swim or a scenic drive along the coast, where coves and clear water reward exploration.

  15. Day 20

    Villefranche-sur-Mer, France

    Villefranche-sur-Mer makes an unusually graceful first impression: pastel houses rise above one of the Riviera’s deepest natural harbors. Wander the old town’s narrow lanes, then visit the 16th-century citadel and its museums. Jean Cocteau’s painted Chapel of Saint-Pierre adds a distinctive local detail. Nearby trains connect you with Nice; roads lead to Èze and the wider Côte d’Azur.

  16. Day 22

    Barcelona, Spain

    Barcelona is a Mediterranean port city built on Roman foundations, with Gothic lanes and striking modernist architecture. La Rambla runs from Plaça de Catalunya towards the waterfront and the old town. Gaudí’s Sagrada Família and Park Güell show the city at its most distinctive. Set aside time for a market lunch and a walk through El Born, where medieval streets meet lively cafés. Barcelona’s beaches offer a welcome pause between visits.

ms Oosterdam Cruises

Published September 8, 2026
Last updated October 15, 2026
Author: J. Richard


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