Cruises to Panama Canal

Discover Panama Canal, starting from Colón, Panama

Panama Canal Cruises

Sailings that call at Panama Canal, earliest departure first.

346 Sailings Found
Colon, Panama

8 Days One-Way from Colon to Panama City

National Geographic Quest

Departs
December 6th 2026
Duration
7 nights
From
$6,150
per person, double occupancy
Ports of call:
Fort Lauderdale, United States

11 Days One-Way from Fort Lauderdale to Panama City

Viking Mars

Departs
December 7th 2026
Duration
10 nights
From
$3,999
per person, double occupancy
Ports of call: +2 more ports
Fort-de-France, Martinique

13 Days One-Way from Fort-De-France to Colon

Le Laperouse

Departs
December 7th 2026
Duration
12 nights
From
$8,800
per person, double occupancy
Ports of call: +4 more ports

Why Book With Waterways Cruise?

Four decades of expertise, one dedicated advisor, and every detail handled, from your front door to the gangway and back.

Personal Service

Cruise Concierge

A dedicated advisor who learns your name, your travel style and your preferences, then stays with you from the first conversation to the day you return home. Not a call center. Never a stranger.

Tailor-Made

100% Custom‑Built

No cookie-cutter packages. Flights, hotels, transfers and shore days are designed from scratch around how you actually like to travel, then refined until the trip feels like yours.

Expertise

40+ Years in Travel

Founded by J. Richard, a four-decade veteran of the travel industry, and focused solely on premium river and ocean cruising. Decades of ship and itinerary knowledge go into every recommendation.

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Book With Total Confidence

A travel agency that is a proud member of Signature Travel Network, CLIA, ASTA and IATA.

Puntarenas, Costa Rica

11 Days One-Way from Puntarenas to Colon

Le Bellot

Departs
December 8th 2026
Duration
10 nights
From
$7,930
per person, double occupancy
Ports of call:
Fort Lauderdale, United States

17 Days One-Way from Fort Lauderdale to Los Angeles

Island Princess

Departs
December 12th 2026
Duration
16 nights
From
$1,369
per person, double occupancy
Ports of call: +3 more ports
Oranjestad Aruba, Aruba

9 Days One-Way from Oranjestad Aruba to Panama City

Star Legend

Departs
December 12th 2026
Duration
8 nights
From
$4,006
per person, double occupancy
Ports of call:
Oranjestad Aruba, Aruba

17 Days One-Way from Oranjestad Aruba to Puntarenas

Star Legend

Departs
December 12th 2026
Duration
16 nights
From
$6,636
per person, double occupancy
Ports of call: +6 more ports
Puntarenas, Costa Rica

8 Days One-Way from Puntarenas to Colon

Wind Star

Departs
December 12th 2026
Duration
7 nights
From
$3,345
per person, double occupancy
Ports of call: +1 more port
Panama City, Panama

8 Days One-Way from Panama City to Colon

National Geographic Quest

Departs
December 13th 2026
Duration
7 nights
From
$6,150
per person, double occupancy
Ports of call:
Panama City, Panama

11 Days One-Way from Panama City to West Palm Beach

Viking Mars

Departs
December 17th 2026
Duration
10 nights
From
$3,599
per person, double occupancy
Ports of call: +2 more ports
Miami, United States

19 Days One-Way from Miami to San Francisco

Azamara Quest

Departs
December 18th 2026
Duration
18 nights
From
$3,999
per person, double occupancy
Ports of call: +3 more ports
Panama City, Panama

8 Days One-Way from Panama City to Puntarenas

Star Clipper

Departs
December 19th 2026
Duration
7 nights
From
$2,010
per person, double occupancy
Ports of call: +1 more port
Colon, Panama

11 Days One-Way from Colon to Puntarenas

Le Laperouse

Departs
December 19th 2026
Duration
10 nights
From
$9,370
per person, double occupancy
Ports of call:
Miami, United States

37 Days One-Way from Miami to Buenos Aires

Oceania Insignia

Departs
December 19th 2026
Duration
36 nights
From
$11,599
per person, double occupancy
Ports of call: +16 more ports
Miami, United States

15 Days One-Way from Miami to Callao-Lima

Oceania Insignia

Departs
December 19th 2026
Duration
14 nights
From
$4,399
per person, double occupancy
Ports of call: +4 more ports
San Diego, United States

16 Days One-Way from San Diego to Fort Lauderdale

ms Zaandam

Departs
December 19th 2026
Duration
15 nights
From
$2,174
per person, double occupancy
Ports of call: +3 more ports
Panama City, Panama

9 Days One-Way from Panama City to Puntarenas

Star Legend

Departs
December 20th 2026
Duration
8 nights
From
$3,782
per person, double occupancy
Ports of call: +1 more port
Cartagena Colombia, Colombia

8 Days Cartagena Colombia, Colombia Round Trip

Grandeur Of The Seas

Departs
December 20th 2026
Duration
7 nights
From
$943
per person, double occupancy
Ports of call: