Florida Cruise from Miami to San Francisco — 19 Days

18 nights · Florida · Departs Miami (USA) · Visiting Cabo Rojo-Pedernales, Cartagena Colombia, Panama Canal, Puntarenas, Puerto Quetzal, Puerto Vallarta, San Diego, San Francisco · Aboard Azamara Cruises on the Azamara Quest

Azamara Cruises logo
Cruise lineAzamara Cruises
ShipAzamara Quest
Duration18 nights
Port calls9
Departures1 sailings
From fare$3,999 per person
Year built2000
Guests794
Cabins361
Crew408
Length181 m
Beam25 m
Cruising speed18.0 kn
  1. Day 1

    Miami, USA

    Miami rewards travelers who look beyond its cruise terminals. South Beach pairs pastel Art Deco hotels with Ocean Drive; Little Havana serves Cuban coffee and music along Calle Ocho. The Pérez Art Museum Miami and nearby Design District reveal the city’s creative ambition. For a change of pace, Biscayne Bay and the Everglades place vivid natural landscapes within reach.

  2. Day 4

    Cabo Rojo-Pedernales

    At the Dominican Republic’s southwestern edge, Cabo Rojo leads to a coast still defined by space, sea and silence. Here, the reward is not a busy resort strip but the wild scenery of Pedernales. Bahía de las Águilas pairs clear water with a long sweep of pale sand. It lies within Jaragua National Park, part of a protected landscape that rewards unhurried exploration. Distances are considerable and services limited, so plan excursions carefully and bring water, sun protection and patience.

  3. Day 6

    Cartagena Colombia, Colombia

    A short ride from Cartagena’s cruise port brings you to its UNESCO-listed historic centre and handsome colonial streets. Inside the old walls, flower-draped balconies, shaded plazas and broad stone lanes lead to cafés, churches and lively markets. Visit Castillo San Felipe de Barajas, the great fortress built to defend the harbor, then explore colorful Getsemaní. Come early, before the midday heat settles over the plazas, and save time for a cool drink beside the Caribbean.

  4. Day 7

    Panama Canal, Panama

    Few journeys change your sense of scale like a passage through the Panama Canal. This 50-mile waterway links the Atlantic and Pacific, lifting ships through locks and across Gatun Lake. Watch the gates close, water rise, and a vast vessel move within inches of concrete walls. On deck, the engineering is the spectacle; beyond it, rainforest edges the route. Bring binoculars, and stay outside for the crossing.

  5. Day 9

    Puntarenas

    Step ashore in Puntarenas, Costa Rica’s long, narrow port city on the Pacific coast. From here, rainforest reserves, coffee country and the Nicoya Peninsula lie within reach. Walk the waterfront promenade for seafood and views across the Gulf of Nicoya. Or head inland to Monteverde’s cloud forest. Plan one excursion and allow time for the road; Puntarenas is best enjoyed at an unhurried pace.

  6. Day 11

    Puerto Quetzal, Guatemala

    Puerto Quetzal is Guatemala’s Pacific gateway, a working port backed by volcanic highlands. Most visitors head inland to Antigua, where cobbled streets, pastel façades and church ruins preserve a distinctive colonial setting. The drive takes roughly 90 minutes, depending on traffic. Closer to the coast, excursions visit fishing villages and black-sand beaches. Choose Antigua for architecture and history, or stay coastal for a closer look at everyday life in Guatemala.

  7. Day 14

    Puerto Vallarta, Mexico

    Puerto Vallarta sits between the Sierra Madre mountains and Banderas Bay. That setting brings jungle-clad slopes, broad beaches and memorable Pacific views. Begin in the historic center, where cobbled streets lead to the landmark Church of Our Lady of Guadalupe. Follow the Malecón, a seafront promenade lined with sculptures, cafés and galleries. For a taste of the coast, settle in for fresh seafood and watch the bay.

  8. Day 17

    San Diego, USA

    San Diego makes an easy first impression: a working harbor, sunlit waterfront and Pacific air. From the cruise terminal, the USS Midway Museum and lively Embarcadero are close at hand. Balboa Park brings world-class museums, gardens and the San Diego Zoo together in one grand setting. In the Gaslamp Quarter, Victorian façades frame restaurants and bars. Nearby neighborhoods reveal Mexican heritage and coastal ease.

  9. Day 19

    San Francisco, USA

    San Francisco rewards visitors who look beyond the postcard. Ride a cable car over steep streets, then explore Chinatown, North Beach, or the Ferry Building’s stalls. The Golden Gate Bridge frames the bay, while Alcatraz offers a stark look at the city’s past. For a quieter hour, walk the waterfront or cross to Sausalito by ferry. Few ports make a day ashore feel so varied—and so distinctly Californian.

Azamara Quest Cruises

Published September 3, 2026
Last updated October 3, 2026
Author: J. Richard


Cruise Disclosure

Good to know: Prices are quoted per person based on double occupancy and include all applicable taxes and fees. Availability and prices can change quickly, so please continue through the booking process to confirm the latest availability and pricing before you pay.

We work hard to make sure everything on this website is accurate and up to date. However, some information may be incomplete or inaccurate, including details supplied by third parties or otherwise outside our control, and we cannot be held responsible for such errors. We work with 41 cruise line operators, that are providing cruises on 585 ships visiting 1,731 ports across 7,194 unique cruises, creating 13,822 itineraries. This is a great deal of data to continually update daily from our suppliers. If a pricing error, misrepresentation, or omission occurs, we reserve the right to adjust the pricing, correct the information, or cancel or decline any booking made in error, with notice to you. Thank you for your understanding!