Cruises from Colón

6 cruise lines and 12 ships sailing from Colón, Panama

Cruises visiting Colón

Colón puts you at Panama’s Caribbean gateway, where the Atlantic meets the Panama Canal. At Agua Clara Locks, watch ships pass through the expanded canal toward Gatun Lake. Nearby, Portobelo and San Lorenzo preserve Spanish colonial fortifications built to guard Caribbean trade routes. Colón is best approached as a gateway, with its strongest draws found in the canal, historic coast and surrounding rainforest.

Cruises from Colón, Panama

Sailings departing from Colón, earliest departure first.

26 Sailings Found
Colon, Panama

20 Days One-Way from Colon to Valparaiso-Santiago

Hanseatic Inspiration

Departs
October 26th 2028
Duration
19 nights
From
$12,884
per person, double occupancy
Ports of call: +3 more ports
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Colon, Panama

15 Days One-Way from Colon to Panama City

ms Europa

Departs
December 17th 2028
Duration
14 nights
Request Exclusive Rates
Ports of call: +7 more ports
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Cruise lines embarking (starting) at Colón (6)

Cruise lineCategoryTypeShips departing from Colón
Ponant Cruises Luxury Ocean L'Austral (no upcoming dates — contact a Waterways Cruise consultant for additional dates on L'Austral cruises departing Colón), Le Bellot, Le Bougainville, Le Laperouse
Hapag-Lloyd Cruises Premium Ocean Hanseatic Inspiration, ms Europa
Lindblad Expeditions Premium Expedition National Geographic Quest
Windstar Cruises Premium Ocean Star Legend, Star Pride, Wind Star
Royal Caribbean Contemporary Ocean Grandeur Of The Seas
Star Clippers Ocean Star Clipper

The complete Waterways Cruise destination guide to Colón, Panama →

6
Cruise lines
12
Ships departing

Published August 18, 2026