Cruises from Colón

6 cruise lines and 12 ships sailing from Colón, Panama

Cruises visiting Colón

Colón puts you at Panama’s Caribbean gateway, where the Atlantic meets the Panama Canal. At Agua Clara Locks, watch ships pass through the expanded canal toward Gatun Lake. Nearby, Portobelo and San Lorenzo preserve Spanish colonial fortifications built to guard Caribbean trade routes. Colón is best approached as a gateway, with its strongest draws found in the canal, historic coast and surrounding rainforest.

Cruises from Colón, Panama

Sailings departing from Colón, earliest departure first.

26 Sailings Found
Colon, Panama

8 Days Colon, Panama Round Trip

Grandeur Of The Seas

Departs
October 31st 2026
Duration
7 nights
From
$643
per person, double occupancy
Ports of call:
View Voyage & Fares Request a Quote
Colon, Panama

8 Days One-Way from Colon to Puntarenas

Le Bellot

Departs
November 7th 2026
Duration
7 nights
From
$5,880
per person, double occupancy
Ports of call:
View Voyage & Fares Request a Quote
Colon, Panama

19 Days One-Way from Colon to Valparaiso-Santiago

Hanseatic Inspiration

Departs
November 9th 2026
Duration
18 nights
From
$31,240
per person, double occupancy
Ports of call: +2 more ports
View Voyage & Fares Request a Quote

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Colon, Panama

11 Days Colon, Panama Round Trip

Grandeur Of The Seas

Departs
November 14th 2026
Duration
10 nights
From
$1,208
per person, double occupancy
Ports of call:
View Voyage & Fares Request a Quote
Colon, Panama

11 Days One-Way from Colon to Puntarenas

Le Bellot

Departs
November 21st 2026
Duration
10 nights
From
$7,660
per person, double occupancy
Ports of call:
View Voyage & Fares Request a Quote
Colon, Panama

8 Days One-Way from Colon to Puntarenas

Wind Star

Departs
December 5th 2026
Duration
7 nights
From
$3,520
per person, double occupancy
Ports of call: +1 more port
View Voyage & Fares Request a Quote
Colon, Panama

8 Days One-Way from Colon to Panama City

National Geographic Quest

Departs
December 6th 2026
Duration
7 nights
From
$6,150
per person, double occupancy
Ports of call:
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Colon, Panama

11 Days One-Way from Colon to Puntarenas

Le Laperouse

Departs
December 19th 2026
Duration
10 nights
From
$9,370
per person, double occupancy
Ports of call:
View Voyage & Fares Request a Quote
Colon, Panama

8 Days One-Way from Colon to Puntarenas

National Geographic Quest

Departs
December 20th 2026
Duration
7 nights
From
$6,228
per person, double occupancy
Ports of call:
View Voyage & Fares Request a Quote
Colon, Panama

8 Days One-Way from Colon to Puntarenas

Star Legend

Departs
January 5th 2027
Duration
7 nights
From
$3,018
per person, double occupancy
Ports of call: +1 more port
View Voyage & Fares Request a Quote
Colon, Panama

8 Days One-Way from Colon to Puntarenas

Le Laperouse

Departs
January 15th 2027
Duration
7 nights
From
$6,230
per person, double occupancy
Ports of call:
View Voyage & Fares Request a Quote
Colon, Panama

5 Days One-Way from Colon to Panama City

National Geographic Quest

Departs
January 17th 2027
Duration
4 nights
From
$6,125
per person, double occupancy
Ports of call:
View Voyage & Fares Request a Quote

Cruise lines embarking (starting) at Colón (6)

Cruise lineCategoryTypeShips departing from Colón
Ponant Cruises Luxury Ocean L'Austral (no upcoming dates — contact a Waterways Cruise consultant for additional dates on L'Austral cruises departing Colón), Le Bellot, Le Bougainville, Le Laperouse
Hapag-Lloyd Cruises Premium Ocean Hanseatic Inspiration, ms Europa
Lindblad Expeditions Premium Expedition National Geographic Quest
Windstar Cruises Premium Ocean Star Legend, Star Pride, Wind Star
Royal Caribbean Contemporary Ocean Grandeur Of The Seas
Star Clippers Ocean Star Clipper

The complete Waterways Cruise destination guide to Colón, Panama →

6
Cruise lines
12
Ships departing

Published August 18, 2026