Cruises from San Diego

8 cruise lines and 14 ships sailing from San Diego, United States

Cruises visiting San Diego

San Diego makes an easy first impression: a working harbor, sunlit waterfront and Pacific air. From the cruise terminal, the USS Midway Museum and lively Embarcadero are close at hand. Balboa Park brings world-class museums, gardens and the San Diego Zoo together in one grand setting. In the Gaslamp Quarter, Victorian façades frame restaurants and bars. Nearby neighborhoods reveal Mexican heritage and coastal ease.

Cruises from San Diego, United States

Sailings departing from San Diego, earliest departure first.

56 Sailings Found
San Diego, United States

10 Days San Diego, USA Round Trip

Crystal Serenity

Departs
December 21st 2026
Duration
9 nights
From
$6,200
per person, double occupancy
Ports of call:
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San Diego, United States

19 Days San Diego, USA Round Trip

Crystal Serenity

Departs
December 21st 2026
Duration
18 nights
Request Exclusive Rates
Ports of call: +2 more ports
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San Diego, United States

8 Days San Diego, USA Round Trip

Norwegian Star

Departs
December 26th 2026
Duration
7 nights
From
$629
per person, double occupancy
Ports of call:
View Voyage & Fares Request a Quote

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San Diego, United States

25 Days San Diego, USA Round Trip

ms Koningsdam

Departs
January 2nd 2027
Duration
24 nights
From
$2,669
per person, double occupancy
Ports of call: +4 more ports
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San Diego, United States

16 Days One-Way from San Diego to Callao-Lima

Crystal Serenity

Departs
January 8th 2027
Duration
15 nights
From
$8,300
per person, double occupancy
Ports of call: +5 more ports
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San Diego, United States

31 Days One-Way from San Diego to Papeete

Crystal Serenity

Departs
January 8th 2027
Duration
30 nights
From
$17,000
per person, double occupancy
Ports of call: +11 more ports
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San Diego, United States

18 Days San Diego, USA Round Trip

ms Koningsdam

Departs
January 9th 2027
Duration
17 nights
From
$1,894
per person, double occupancy
Ports of call: +1 more port
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San Diego, United States

8 Days San Diego, USA Round Trip

ms Zuiderdam

Departs
January 16th 2027
Duration
7 nights
From
$844
per person, double occupancy
Ports of call:
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San Diego, United States

15 Days San Diego, USA Round Trip

ms Zuiderdam

Departs
January 16th 2027
Duration
14 nights
From
$1,529
per person, double occupancy
Ports of call:
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San Diego, United States

19 Days San Diego, USA Round Trip

ms Koningsdam

Departs
January 26th 2027
Duration
18 nights
From
$2,029
per person, double occupancy
Ports of call: +1 more port
View Voyage & Fares Request a Quote
San Diego, United States

17 Days One-Way from San Diego to Fort Lauderdale

Island Princess

Departs
January 29th 2027
Duration
16 nights
From
$2,189
per person, double occupancy
Ports of call: +3 more ports
View Voyage & Fares Request a Quote
San Diego, United States

16 Days One-Way from San Diego to Miami

ms Zuiderdam

Departs
January 30th 2027
Duration
15 nights
From
$1,924
per person, double occupancy
Ports of call: +4 more ports
View Voyage & Fares Request a Quote

Cruise lines embarking (starting) at San Diego (8)

Cruise lineCategoryTypeShips departing from San Diego
Silversea Cruises Ultra Luxury Ocean Silver Whisper
Azamara Cruises Premium Ocean Azamara Quest
Crystal Cruises Premium Ocean Crystal Serenity, Crystal Symphony
Holland America Contemporary Ocean ms Eurodam, ms Koningsdam, ms Nieuw Amsterdam, ms Oosterdam, ms Zaandam, ms Zuiderdam
MSC Cruises Contemporary Ocean MSC Poesia (no upcoming dates — contact a Waterways Cruise consultant for additional dates on MSC Poesia cruises departing San Diego)
Norwegian Cruise Line Contemporary Ocean Norwegian Star
Princess Cruises Contemporary Ocean Island Princess
Royal Caribbean Contemporary Ocean Serenade Of The Seas

The complete Waterways Cruise destination guide to San Diego, United States →

8
Cruise lines
14
Ships departing

Published August 16, 2026