Cruises from San Diego

8 cruise lines and 14 ships sailing from San Diego, United States

Cruises visiting San Diego

San Diego makes an easy first impression: a working harbor, sunlit waterfront and Pacific air. From the cruise terminal, the USS Midway Museum and lively Embarcadero are close at hand. Balboa Park brings world-class museums, gardens and the San Diego Zoo together in one grand setting. In the Gaslamp Quarter, Victorian façades frame restaurants and bars. Nearby neighborhoods reveal Mexican heritage and coastal ease.

Cruises from San Diego, United States

Sailings departing from San Diego, earliest departure first.

56 Sailings Found
San Diego, United States

36 Days One-Way from San Diego to London-Tilbury

Azamara Quest

Departs
May 24th 2027
Duration
35 nights
From
$12,659
per person, double occupancy
Ports of call: +13 more ports
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San Diego, United States

18 Days One-Way from San Diego to Miami

Azamara Quest

Departs
May 24th 2027
Duration
17 nights
From
$4,939
per person, double occupancy
Ports of call: +3 more ports
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San Diego, United States

12 Days One-Way from San Diego to Panama City

Crystal Serenity

Departs
August 9th 2027
Duration
11 nights
From
$5,030
per person, double occupancy
Ports of call: +2 more ports
View Voyage & Fares Request a Quote

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San Diego, United States

26 Days One-Way from San Diego to New York

Crystal Serenity

Departs
August 9th 2027
Duration
25 nights
From
$10,670
per person, double occupancy
Ports of call: +11 more ports
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San Diego, United States

16 Days One-Way from San Diego to Tampa

Serenade Of The Seas

Departs
October 7th 2027
Duration
15 nights
From
$1,947
per person, double occupancy
Ports of call: +2 more ports
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San Diego, United States

17 Days One-Way from San Diego to Fort Lauderdale

ms Eurodam

Departs
October 7th 2027
Duration
16 nights
From
$1,699
per person, double occupancy
Ports of call: +4 more ports
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San Diego, United States

22 Days One-Way from San Diego to San Antonio

ms Nieuw Amsterdam

Departs
October 12th 2027
Duration
21 nights
From
$2,784
per person, double occupancy
Ports of call: +6 more ports
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San Diego, United States

36 Days One-Way from San Diego to Buenos Aires

ms Nieuw Amsterdam

Departs
October 12th 2027
Duration
35 nights
From
$4,249
per person, double occupancy
Ports of call: +15 more ports
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San Diego, United States

36 Days San Diego, USA Round Trip

ms Zaandam

Departs
October 14th 2027
Duration
35 nights
From
$4,324
per person, double occupancy
Ports of call: +8 more ports
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San Diego, United States

6 Days San Diego, USA Round Trip

ms Koningsdam

Departs
December 18th 2027
Duration
5 nights
From
$769
per person, double occupancy
Ports of call:
View Voyage & Fares Request a Quote
San Diego, United States

13 Days San Diego, USA Round Trip

ms Koningsdam

Departs
December 18th 2027
Duration
12 nights
From
$1,954
per person, double occupancy
Ports of call:
View Voyage & Fares Request a Quote
San Diego, United States

16 Days One-Way from San Diego to Miami

ms Zaandam

Departs
December 18th 2027
Duration
15 nights
From
$2,674
per person, double occupancy
Ports of call: +3 more ports
View Voyage & Fares Request a Quote

Cruise lines embarking (starting) at San Diego (8)

Cruise lineCategoryTypeShips departing from San Diego
Silversea Cruises Ultra Luxury Ocean Silver Whisper
Azamara Cruises Premium Ocean Azamara Quest
Crystal Cruises Premium Ocean Crystal Serenity, Crystal Symphony
Holland America Contemporary Ocean ms Eurodam, ms Koningsdam, ms Nieuw Amsterdam, ms Oosterdam, ms Zaandam, ms Zuiderdam
MSC Cruises Contemporary Ocean MSC Poesia (no upcoming dates — contact a Waterways Cruise consultant for additional dates on MSC Poesia cruises departing San Diego)
Norwegian Cruise Line Contemporary Ocean Norwegian Star
Princess Cruises Contemporary Ocean Island Princess
Royal Caribbean Contemporary Ocean Serenade Of The Seas

The complete Waterways Cruise destination guide to San Diego, United States →

8
Cruise lines
14
Ships departing

Published August 16, 2026