Sicily Italy Cruise from Palermo to Santos — 23 Days

22 nights · Sicily Italy · Departs Palermo (Italy) · Visiting Naples, Livorno, Marseille, Barcelona, Malaga, Santa Cruz de Tenerife, Maceio, Salvador de Bahia, Rio de Janeiro, Ilhabela, Santos · Aboard MSC Cruises on the MSC Virtuosa

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Cruise lineMSC Cruises
ShipMSC Virtuosa
Duration22 nights
Port calls12
Departures1 sailings
From fare$8,728 per person
Year built2021
Guests6334
Cabins2421
Crew1704
Length331 m
Beam43 m
Cruising speed23.0 kn
  1. Day 1

    Palermo, Italy

    Palermo rewards curious travellers with a vivid mix of Arab-Norman architecture, lively markets and Sicilian cooking. Start at the cathedral, where Norman, Gothic and Baroque details reflect the city’s layered past. Then walk through the Capo market or visit the Palatine Chapel, famed for its Byzantine mosaics. Leave time for pasta con le sarde or arancini; Palermo’s strongest impressions often arrive at the table.

  2. Day 2

    Naples, Italy

    Naples puts its history within reach: the port opens onto a compact city framed by Mount Vesuvius and the bay. UNESCO-listed streets lead to churches, palaces and the everyday theatre of southern Italian life. At the National Archaeological Museum, mosaics and objects from Pompeii and Herculaneum bring the Roman world sharply into focus. Stay close for Neapolitan pizza, or use Naples as a springboard to Pompeii, Herculaneum and Capri.

  3. Day 3

    Livorno, Italy

    Livorno rewards those who look beyond the cruise terminal. Its canals, built in the style of Venice, wind through historic Venezia Nuova. The seafront promenade leads to Terrazza Mascagni, where black-and-white paving frames the sea. At Mercato Centrale, locals shop beneath a vast iron-and-glass roof. Try cacciucco, the city’s rich fish stew. Florence and Pisa are within reach, but Livorno merits time of its own.

  4. Day 4

    Marseille, France

    Marseille is France’s oldest city, founded by Greek settlers around 600 BC, and it still faces the Mediterranean with confidence. Begin at the Vieux-Port, where fishing boats share the waterfront with cafés and ferries bound for nearby islands. Climb to Notre-Dame de la Garde for sweeping views, or explore Le Panier’s narrow lanes and lively squares. The Calanques’ limestone coves lie beyond the city; local markets bring Provençal flavors closer.

  5. Day 5

    Barcelona, Spain

    Barcelona is a Mediterranean port city built on Roman foundations, with Gothic lanes and striking modernist architecture. La Rambla runs from Plaça de Catalunya towards the waterfront and the old town. Gaudí’s Sagrada Família and Park Güell show the city at its most distinctive. Set aside time for a market lunch and a walk through El Born, where medieval streets meet lively cafés. Barcelona’s beaches offer a welcome pause between visits.

  6. Day 7

    Malaga, Spain

    Málaga is more than a gateway to Andalusia; it is a port city with a confident life of its own. In the old centre, the Roman Theatre sits below the Moorish Alcazaba, while the cathedral rises above nearby streets. Visit the Picasso Museum or his birthplace, then try grilled sardines and local wine at a pavement table. The Mediterranean is close: city beaches, Atarazanas Market and palm-lined promenades make lingering easy.

  7. Day 9

    Santa Cruz de Tenerife, Spain

    Santa Cruz de Tenerife is more than an island gateway. This Atlantic capital rewards a closer look. Browse the stalls at Mercado de Nuestra Señora de África, then follow the old streets towards Plaza de España. Its broad avenues, shaded plazas and market cafés make wandering pleasantly straightforward. Modern landmarks include the sculptural Auditorio de Tenerife, while palm-lined parks offer a welcome pause. Mount Teide rises inland; the golden sands of Las Teresitas lie within reach.

  8. Day 16

    Maceio, Brazil

    Maceió, capital of Alagoas, sits between the Atlantic and Mundaú Lagoon, with turquoise water close at hand. At Pajuçara, traditional jangadas carry visitors to offshore natural pools at low tide. Nearby Ponta Verde pairs a beachfront promenade with cafés and seafood restaurants. Explore the historic center’s colonial-era churches, or visit the Museu Théo Brandão, whose collection celebrates Alagoas’s folk culture. Then return to the shore for grilled fish and sunset over the water.

  9. Day 18

    Salvador de Bahia, Brazil

    Salvador rewards curious travellers with Brazil’s strongest blend of African heritage, Portuguese architecture and Atlantic spirit. In Pelourinho, within the city’s UNESCO-listed historic centre, pastel façades and baroque churches line steep cobbled streets. Ride the Elevador Lacerda from the upper city to the waterfront, where views open across Baía de Todos-os-Santos. Try acarajé, crisp black-eyed-pea fritters sold by baianas in traditional dress. Music carries traditions shaped by Candomblé and samba.

  10. Day 21

    Rio de Janeiro, Brazil

    Granite peaks rise above Guanabara Bay; the city reaches toward the Atlantic. From the port, the landmarks are unmistakable: Sugarloaf Mountain guards the bay, and Christ the Redeemer watches from Corcovado. Balance the grand views with street-level pleasures: Copacabana, Ipanema, and the leafy avenues of the South Zone. Choose one or two sights, then leave room for a long lunch and the city’s beach culture.

  11. Day 22

    Ilhabela, Brazil

    Ilhabela sits off Brazil’s São Paulo coast, reached by ferry from São Sebastião. Much of the island lies within a protected state park, where Atlantic rainforest rises behind beaches and waterfalls. In the historic village of Vila, colonial-era buildings frame cafés, shops and a waterfront promenade. Beyond town, choose a swim in clear coves, a forest trail or a boat trip to quieter shores. Sailors prize Ilhabela’s breezes; divers explore nearby shipwrecks.

  12. Day 23

    Santos, Brazil

    Often the gateway to São Paulo, Santos rewards a closer look before you head inland. Brazil’s busiest port has shaped national trade for generations, especially through coffee. Its story unfolds at the grand former Bolsa do Café. Along the waterfront, a long garden-lined promenade frames broad beaches and everyday city life. The historic center offers churches and old commercial streets, while nearby São Vicente recalls Brazil’s earliest colonial years.

MSC Virtuosa Cruises

Published August 9, 2026
Last updated October 3, 2026
Author: J. Richard


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