Italy Cruise from Civitavecchia to Istanbul — 8 Days

7 nights · Italy · Departs Civitavecchia-Rome (Italy) · Visiting Naples, Messina, Valletta, Piraeus-Athens, Lesbos Island, Istanbul · Aboard Oceania Cruises on the Oceania Sirena

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Oceania Sirena
Civitavecchia Cruise Port: Shore Excursions & Expert Guide Naples Cruise Port: Pompeii, Pizza & Expert Shore Guide Messina Cruise Port: Shore Excursions & Expert Guide Valletta Cruise Port: Shore Excursions & Expert Guide
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Cruise lineOceania Cruises
ShipOceania Sirena
Duration7 nights
Port calls7
Departures1 sailings
Year built1999
Guests803
Cabins349
Crew375
Length181 m
Beam25 m
Cruising speed20.0 kn
  1. Day 1

    Civitavecchia-Rome, Italy

    Your ship docks at Civitavecchia, Rome’s seaport, about 50 miles northwest of the capital. Rome’s great monuments are within reach, but the port town rewards a closer look. Walk the waterfront to Forte Michelangelo, a 16th-century fortress begun under Pope Julius II; explore the old streets and market. Prefer a quieter day? The town’s seafront and nearby beaches offer an easy change of pace. Choose Rome for art and antiquity, or Civitavecchia for coastal life beyond the terminal.

  2. Day 2

    Naples, Italy

    Naples puts its history within reach: the port opens onto a compact city framed by Mount Vesuvius and the bay. UNESCO-listed streets lead to churches, palaces and the everyday theatre of southern Italian life. At the National Archaeological Museum, mosaics and objects from Pompeii and Herculaneum bring the Roman world sharply into focus. Stay close for Neapolitan pizza, or use Naples as a springboard to Pompeii, Herculaneum and Capri.

  3. Day 3

    Messina, Italy

    Messina faces Calabria across the narrow Strait of Messina, with mainland Italy visible from its waterfront. At noon, figures move across the cathedral’s clock tower, a daily spectacle best seen from the square. Nearby, Montorsoli’s 16th-century Fountain of Orion rewards a closer look. Excursions reach Taormina and Mount Etna, but Messina’s compact center also merits an unhurried walk.

  4. Day 4

    Valletta, Malta

    Valletta makes a powerful first impression, its honey-coloured walls rising above Grand Harbour. Founded by the Knights of St John in 1566, Malta’s compact capital rewards exploration on foot. Enter St John’s Co-Cathedral for Caravaggio’s monumental paintings, then follow Republic Street to cafés, palaces and the Upper Barrakka Gardens. From the terraces, watch ferries cross the harbour and look towards the Three Cities. Allow time for steep lanes and quiet side streets.

  5. Day 6

    Piraeus-Athens, Greece

    Piraeus is Athens’ working harbour, not a resort port—and that is its appeal. From here, the capital’s ancient landmarks are within reach, while the waterfront keeps its own busy, distinctly Greek character. Visit the Archaeological Museum of Piraeus, then linger over grilled fish in Mikrolimano, a small harbour lined with tavernas. Metro connections make central Athens straightforward. Or stay near the water and watch ferries depart for the islands.

  6. Day 7

    Lesbos Island, Greece

    Lesbos is Greece’s third-largest island, yet its pleasures feel distinctly local. In Mytilene, the island’s capital, neoclassical houses rise above a harbor watched over by a medieval castle. Visit the Archaeological Museum, then follow the waterfront into lanes scented with coffee and grilled fish. Beyond town, olive groves lead to seaside villages and Plomari, famed for ouzo. The western Petrified Forest, a UNESCO Global Geopark, reveals a landscape unlike the Aegean’s familiar blue-and-white postcard.

  7. Day 8

    Istanbul, Turkey

    Istanbul makes a compelling first impression: minarets rise above the Bosphorus, while ferries cross between Europe and Asia. On the historic peninsula, Hagia Sophia, the Blue Mosque and Topkapi Palace place centuries of empire within walking distance. Istanbul rewards curiosity beyond its landmarks. Browse the Grand Bazaar, linger over Turkish coffee, then take a ferry to the Asian shore. Allow time for traffic and queues; the city’s scale is part of the experience.

Oceania Sirena Cruises

Published September 15, 2026
Last updated October 3, 2026
Author: J. Richard

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