Greece Cruise from Piraeus to Barcelona — 15 Days

14 nights · Greece · Departs Piraeus-Athens (Greece) · Visiting Mykonos Island, Bozcaada Island, Istanbul, Lesbos Island, Kusadasi, Valletta, Messina, Sorrento, Civitavecchia-Rome, La Spezia, Monte Carlo, Barcelona · Aboard Regent Seven Seas Cruises on the Seven Seas Mariner

Regent Seven Seas Cruises logo
Seven Seas Mariner
Piraeus Cruise Port Mykonos Cruise Port Bozcaada Cruise Port: Shore Excursions & Expert Guide Istanbul Cruise Port: Shore Excursions & Expert Guide
13 Photos

Image courtesy of Regent Seven Seas Cruises ©

Cruise lineRegent Seven Seas Cruises
ShipSeven Seas Mariner
Duration14 nights
Port calls13
From fare$31,598 per person
Year built2001
Guests779
Cabins354
Crew445
Length216 m
Beam28 m
Cruising speed21.0 kn
  1. Day 1

    Piraeus-Athens, Greece

    Piraeus is Athens’ working harbour, not a resort port—and that is its appeal. From here, the capital’s ancient landmarks are within reach, while the waterfront keeps its own busy, distinctly Greek character. Visit the Archaeological Museum of Piraeus, then linger over grilled fish in Mikrolimano, a small harbour lined with tavernas. Metro connections make central Athens straightforward. Or stay near the water and watch ferries depart for the islands.

  2. Day 2

    Mykonos Island, Greece

    Mykonos rewards an early start: whitewashed lanes, blue-domed churches and waterfront cafés are quieter before the cruise crowds arrive. In Little Venice, old captains’ houses lean over the Aegean, while the island’s windmills stand above the harbor. Beyond town, beaches range from lively Psarou to the broad sands of Elia. Take a short boat ride to Delos, where ancient sanctuaries and marble streets mark one of Greece’s great archaeological sites.

  3. Day 3

    Bozcaada Island, Turkey

    Bozcaada lies in the northern Aegean, a short ferry ride from Geyikli on Turkey’s Çanakkale coast. Its harbor is watched by a castle, rebuilt under Ottoman rule and visible as ferries approach. Beyond the waterfront, lanes pass stone houses, cafés and churches that reflect the island’s Greek and Turkish past. Vineyards cover the inland slopes, while Ayazma Beach offers a swim in clear Aegean water.

  4. Day 4

    Istanbul, Turkey

    Istanbul makes a compelling first impression: minarets rise above the Bosphorus, while ferries cross between Europe and Asia. On the historic peninsula, Hagia Sophia, the Blue Mosque and Topkapi Palace place centuries of empire within walking distance. Istanbul rewards curiosity beyond its landmarks. Browse the Grand Bazaar, linger over Turkish coffee, then take a ferry to the Asian shore. Allow time for traffic and queues; the city’s scale is part of the experience.

  5. Day 5

    Lesbos Island, Greece

    Lesbos is Greece’s third-largest island, yet its pleasures feel distinctly local. In Mytilene, the island’s capital, neoclassical houses rise above a harbor watched over by a medieval castle. Visit the Archaeological Museum, then follow the waterfront into lanes scented with coffee and grilled fish. Beyond town, olive groves lead to seaside villages and Plomari, famed for ouzo. The western Petrified Forest, a UNESCO Global Geopark, reveals a landscape unlike the Aegean’s familiar blue-and-white postcard.

  6. Day 6

    Kusadasi, Turkey

    Kuşadası puts the Aegean within reach, with a lively waterfront and one of Turkey’s most celebrated ancient cities nearby. Ephesus lies about 20 kilometres inland, where marble avenues lead to the Library of Celsus and Great Theatre. Back in town, browse the bazaar, then follow the causeway to Pigeon Island and its historic fortress. The harbour-facing promenade offers an easy place to linger over the Aegean light.

  7. Day 8

    Valletta, Malta

    Valletta makes a powerful first impression, its honey-coloured walls rising above Grand Harbour. Founded by the Knights of St John in 1566, Malta’s compact capital rewards exploration on foot. Enter St John’s Co-Cathedral for Caravaggio’s monumental paintings, then follow Republic Street to cafés, palaces and the Upper Barrakka Gardens. From the terraces, watch ferries cross the harbour and look towards the Three Cities. Allow time for steep lanes and quiet side streets.

  8. Day 9

    Messina, Italy

    Messina faces Calabria across the narrow Strait of Messina, with mainland Italy visible from its waterfront. At noon, figures move across the cathedral’s clock tower, a daily spectacle best seen from the square. Nearby, Montorsoli’s 16th-century Fountain of Orion rewards a closer look. Excursions reach Taormina and Mount Etna, but Messina’s compact center also merits an unhurried walk.

  9. Day 10

    Sorrento, Italy

    Sorrento rises above the Bay of Naples, facing Mount Vesuvius across water busy with ferries. From here, ferries connect with Capri, while the town rewards a slower day among old lanes, churches, and sea-view terraces. Follow the scent of citrus to shops selling Sorrento lemons, locally made limoncello, and finely crafted marquetry. Then pause over lunch: the region’s seafood and Campanian produce are best enjoyed without hurry.

  10. Day 11

    Civitavecchia-Rome, Italy

    Your ship docks at Civitavecchia, Rome’s seaport, about 50 miles northwest of the capital. Rome’s great monuments are within reach, but the port town rewards a closer look. Walk the waterfront to Forte Michelangelo, a 16th-century fortress begun under Pope Julius II; explore the old streets and market. Prefer a quieter day? The town’s seafront and nearby beaches offer an easy change of pace. Choose Rome for art and antiquity, or Civitavecchia for coastal life beyond the terminal.

  11. Day 12

    La Spezia, Italy

    La Spezia sits at the head of the Gulf of Poets. Here, Liguria’s steep hills meet a sheltered stretch of Mediterranean coast. Its working harbor gives the city a lively maritime character, while cafés and broad streets reward an easy stroll. Trains connect La Spezia with the villages of the Cinque Terre; ferries sail to Portovenere. Allow time for the city itself, not just its celebrated neighbors.

  12. Day 13

    Monte Carlo, Monaco

    Monte Carlo makes a striking first impression, with superyachts in Port Hercule and the Alps rising behind the coast. A short walk leads to Casino Square, where Belle Époque architecture frames the famous casino and designer boutiques. For a quieter contrast, climb to Monaco-Ville for the Prince’s Palace, cathedral and views across the harbor. The principality is compact and easy to explore on foot, though its steep streets reward comfortable shoes.

  13. Day 15

    Barcelona, Spain

    Barcelona is a Mediterranean port city built on Roman foundations, with Gothic lanes and striking modernist architecture. La Rambla runs from Plaça de Catalunya towards the waterfront and the old town. Gaudí’s Sagrada Família and Park Güell show the city at its most distinctive. Set aside time for a market lunch and a walk through El Born, where medieval streets meet lively cafés. Barcelona’s beaches offer a welcome pause between visits.

Seven Seas Mariner Cruises

Published September 16, 2026
Last updated October 13, 2026
Author: J. Richard

Cruise Disclosure

Good to know: Prices are quoted per person based on double occupancy and include all applicable taxes and fees. Availability and prices can change quickly, so please continue through the booking process to confirm the latest availability and pricing before you pay.

We work hard to make sure everything on this website is accurate and up to date. However, some information may be incomplete or inaccurate, including details supplied by third parties or otherwise outside our control, and we cannot be held responsible for such errors. We work with 41 cruise line operators, that are providing cruises on 585 ships visiting 1,731 ports across 7,194 unique cruises, creating 13,822 itineraries. This is a great deal of data to continually update daily from our suppliers. If a pricing error, misrepresentation, or omission occurs, we reserve the right to adjust the pricing, correct the information, or cancel or decline any booking made in error, with notice to you. Thank you for your understanding!