Cruises from Palermo

2 cruise lines and 9 ships sailing from Palermo, Italy

Cruises visiting Palermo

Palermo rewards curious travellers with a vivid mix of Arab-Norman architecture, lively markets and Sicilian cooking. Start at the cathedral, where Norman, Gothic and Baroque details reflect the city’s layered past. Then walk through the Capo market or visit the Palatine Chapel, famed for its Byzantine mosaics. Leave time for pasta con le sarde or arancini; Palermo’s strongest impressions often arrive at the table.

Cruises from Palermo, Italy

Sailings departing from Palermo, earliest departure first.

14 Sailings Found
Palermo, Italy

8 Days Palermo, Italy Round Trip

MSC Seaview

Departs
November 2nd 2026
Duration
7 nights
From
$927
per person, double occupancy
Ports of call:
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Palermo, Italy

8 Days Palermo, Italy Round Trip

MSC Euribia

Departs
November 4th 2026
Duration
7 nights
From
$708
per person, double occupancy
Ports of call:
View Voyage & Fares Request a Quote
Palermo, Italy

8 Days Palermo, Italy Round Trip

MSC Splendida

Departs
November 5th 2026
Duration
7 nights
From
$816
per person, double occupancy
Ports of call:
View Voyage & Fares Request a Quote

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Palermo, Italy

6 Days One-Way from Palermo to Genoa

MSC Seaview

Departs
November 9th 2026
Duration
5 nights
From
$419
per person, double occupancy
Ports of call:
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Palermo, Italy

22 Days One-Way from Palermo to Buenos Aires

MSC Splendida

Departs
November 12th 2026
Duration
21 nights
From
$4,117
per person, double occupancy
Ports of call: +5 more ports
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Palermo, Italy

4 Days One-Way from Palermo to Barcelona

MSC Euribia

Departs
April 7th 2027
Duration
3 nights
From
$189
per person, double occupancy
Ports of call:
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Palermo, Italy

8 Days Palermo, Italy Round Trip

MSC Musica

Departs
April 19th 2027
Duration
7 nights
From
$838
per person, double occupancy
Ports of call:
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Palermo, Italy

8 Days Palermo, Italy Round Trip

MSC Virtuosa

Departs
April 23rd 2027
Duration
7 nights
From
$988
per person, double occupancy
Ports of call:
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Palermo, Italy

6 Days One-Way from Palermo to Valletta

Le Boreal

Departs
June 1st 2027
Duration
5 nights
From
$3,870
per person, double occupancy
Ports of call:
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Palermo, Italy

8 Days One-Way from Palermo to Lavrion

Le Ponant

Departs
June 8th 2027
Duration
7 nights
From
$11,960
per person, double occupancy
Ports of call: +1 more port
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Palermo, Italy

8 Days One-Way from Palermo to Villefranche-Sur-Mer

Le Ponant

Departs
August 24th 2027
Duration
7 nights
From
$14,000
per person, double occupancy
Ports of call: +3 more ports
View Voyage & Fares Request a Quote
Palermo, Italy

23 Days One-Way from Palermo to Santos

MSC Virtuosa

Departs
November 12th 2027
Duration
22 nights
From
$8,728
per person, double occupancy
Ports of call: +6 more ports
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Cruise lines embarking (starting) at Palermo (2)

Cruise lineCategoryTypeShips departing from Palermo
Ponant Cruises Luxury Ocean Le Boreal, Le Ponant
MSC Cruises Contemporary Ocean MSC Euribia, MSC Meraviglia (no upcoming dates — contact a Waterways Cruise consultant for additional dates on MSC Meraviglia cruises departing Palermo), MSC Musica, MSC Seashore, MSC Seaview, MSC Splendida, MSC Virtuosa

The complete Waterways Cruise destination guide to Palermo, Italy →

2
Cruise lines
9
Ships departing

Published September 8, 2026