Portugal Cruise from Lisbon to Piraeus — 25 Days

24 nights · Portugal · Departs Lisbon (Portugal) · Visiting Portimao, Tangier, Melilla, La Goulette-Tunis, Cagliari, Ajaccio, Marseille, Palamos, Barcelona, Toulon, Monte Carlo, Portofino, Livorno, Civitavecchia-Rome, Naples, Messina, Valletta, Souda-Chania, Kusadasi, Piraeus-Athens · Aboard Crystal Cruises on the Crystal Serenity

Crystal Cruises logo
Cruise lineCrystal Cruises
ShipCrystal Serenity
Duration24 nights
Port calls21
Departures1 sailings
From fare$16,000 per person
Year built2003
Guests740
Cabins347
Crew655
Length250 m
Beam32 m
Cruising speed21.0 kn
  1. Day 1

    Lisbon, Portugal

    Lisbon is a city best approached with time and comfortable shoes. Its seven hills rise above the Tagus, linking tiled lanes, grand squares and viewpoints with wide river views. In Alfama, narrow streets preserve the feel of old Lisbon. In Belém, the Jerónimos Monastery and Tower recall Portugal’s age of discovery. Pause for coffee and a warm pastel de nata between sights.

  2. Day 2

    Portimao, Portugal

    Portimão sits where the Arade River meets the Atlantic, in Portugal’s sunlit Algarve. From the quay, Praia da Rocha’s ochre cliffs and broad sands are close at hand. In the old town, tiled façades and cafés frame the Igreja de Nossa Senhora da Conceição. Choose fresh sardines at the waterfront, or cross the river to Ferragudo for a quieter village view. Portimão makes an easy base for exploring the Algarve’s coast without sacrificing a genuine working-town feel.

  3. Day 3

    Tangier, Morocco

    Tangier faces Spain across the Strait of Gibraltar, where the Mediterranean meets the Atlantic. Walk its medina’s steep lanes past whitewashed houses and shops selling leather, ceramics, and spices. At the Kasbah, find sea views and the former sultan’s palace, now a museum. Beyond the old walls, cafés and boulevards recall the city’s international past. Visit the American Legation, the first U.S. diplomatic property abroad. Or drive to Cap Spartel, where Atlantic and Mediterranean waters meet.

  4. Day 4

    Melilla, Spain

    Melilla gives you Spain with North African light and a distinctly different rhythm. Set on Morocco’s Mediterranean coast, this Spanish enclave rewards a day spent on foot. Begin in Melilla la Vieja, the fortified old town, where stone walls frame sea views and quiet lanes. Then look up: Melilla is known for its Modernist architecture, much of it designed by Enrique Nieto. Cafés and waterfront walks offer an easy pause between landmarks.

  5. Day 6

    La Goulette-Tunis, Tunisia

    La Goulette is Tunisia’s principal cruise gateway, set on the Mediterranean just northeast of Tunis. The capital’s old medina, Carthage’s ruins and Sidi Bou Said’s white-and-blue lanes are all within reach. Choose Roman history, Ottoman-era streets or cafés overlooking the sea. Plan around traffic: these sights lie in different directions, and each merits an unhurried visit.

  6. Day 7

    Cagliari, Italy

    Cagliari rewards those who look beyond the waterfront. Sardinia’s capital rises above the Gulf of Angels, its old Castello quarter perched over a working port. Walk the bastions for broad views, then explore the Roman amphitheatre carved into limestone. Below town, Poetto’s long beach meets salt lagoons where flamingos feed. Return for fregola with seafood or bottarga, the island’s prized cured mullet roe.

  7. Day 8

    Ajaccio, France

    Ajaccio brings Corsica’s character within easy reach of the quay. France’s island capital pairs a sheltered gulf with pastel façades, a lively old town and mountain ridges above the harbor. Napoleon Bonaparte was born here in 1769; his birthplace is now a museum. From Place Foch, browse the market before following narrow lanes to the cathedral and waterfront cafés. Allow time for a swim or a scenic drive along the coast, where coves and clear water reward exploration.

  8. Day 9

    Marseille, France

    Marseille is France’s oldest city, founded by Greek settlers around 600 BC, and it still faces the Mediterranean with confidence. Begin at the Vieux-Port, where fishing boats share the waterfront with cafés and ferries bound for nearby islands. Climb to Notre-Dame de la Garde for sweeping views, or explore Le Panier’s narrow lanes and lively squares. The Calanques’ limestone coves lie beyond the city; local markets bring Provençal flavors closer.

  9. Day 10

    Palamos, Spain

    Palamós brings you to the heart of Spain’s Costa Brava, where a working fishing port meets a handsome old town. Its waterfront is famed for the prawns landed here, best sampled at a local table. Walk the promenade, visit the Fishing Museum, or follow coastal paths towards rocky coves and clear water. Girona and medieval villages lie inland, but Palamós rewards a slower day close to the sea.

  10. Day 11

    Barcelona, Spain

    Barcelona is a Mediterranean port city built on Roman foundations, with Gothic lanes and striking modernist architecture. La Rambla runs from Plaça de Catalunya towards the waterfront and the old town. Gaudí’s Sagrada Família and Park Güell show the city at its most distinctive. Set aside time for a market lunch and a walk through El Born, where medieval streets meet lively cafés. Barcelona’s beaches offer a welcome pause between visits.

  11. Day 13

    Toulon, France

    Toulon is a working Mediterranean port, framed by limestone hills and one of Europe’s finest natural harbours. Look beyond the waterfront to the old town, where Cours Lafayette’s market fills the street with Provençal produce. For a wider view, ride the cable car up Mont Faron, then visit its memorial to the 1944 Allied landings. Nearby, the Îles d’Hyères, local beaches and cafés offer an easy-paced taste of coastal Provence.

  12. Day 14

    Monte Carlo, Monaco

    Monte Carlo makes a striking first impression, with superyachts in Port Hercule and the Alps rising behind the coast. A short walk leads to Casino Square, where Belle Époque architecture frames the famous casino and designer boutiques. For a quieter contrast, climb to Monaco-Ville for the Prince’s Palace, cathedral and views across the harbor. The principality is compact and easy to explore on foot, though its steep streets reward comfortable shoes.

  13. Day 15

    Portofino, Italy

    Portofino is a small Ligurian harbour, framed by green hills and pastel façades. On its crescent waterfront, fishing boats share the view with polished yachts. From the piazzetta, lanes climb to Castello Brown, a former fortress overlooking the harbour and coast. Walk on to the lighthouse at Punta del Capo, or take a boat to nearby Santa Margherita Ligure. A table by the water offers the best reason to linger.

  14. Day 16

    Livorno, Italy

    Livorno rewards those who look beyond the cruise terminal. Its canals, built in the style of Venice, wind through historic Venezia Nuova. The seafront promenade leads to Terrazza Mascagni, where black-and-white paving frames the sea. At Mercato Centrale, locals shop beneath a vast iron-and-glass roof. Try cacciucco, the city’s rich fish stew. Florence and Pisa are within reach, but Livorno merits time of its own.

  15. Day 18

    Civitavecchia-Rome, Italy

    Your ship docks at Civitavecchia, Rome’s seaport, about 50 miles northwest of the capital. Rome’s great monuments are within reach, but the port town rewards a closer look. Walk the waterfront to Forte Michelangelo, a 16th-century fortress begun under Pope Julius II; explore the old streets and market. Prefer a quieter day? The town’s seafront and nearby beaches offer an easy change of pace. Choose Rome for art and antiquity, or Civitavecchia for coastal life beyond the terminal.

  16. Day 19

    Naples, Italy

    Naples puts its history within reach: the port opens onto a compact city framed by Mount Vesuvius and the bay. UNESCO-listed streets lead to churches, palaces and the everyday theatre of southern Italian life. At the National Archaeological Museum, mosaics and objects from Pompeii and Herculaneum bring the Roman world sharply into focus. Stay close for Neapolitan pizza, or use Naples as a springboard to Pompeii, Herculaneum and Capri.

  17. Day 20

    Messina, Italy

    Messina faces Calabria across the narrow Strait of Messina, with mainland Italy visible from its waterfront. At noon, figures move across the cathedral’s clock tower, a daily spectacle best seen from the square. Nearby, Montorsoli’s 16th-century Fountain of Orion rewards a closer look. Excursions reach Taormina and Mount Etna, but Messina’s compact center also merits an unhurried walk.

  18. Day 21

    Valletta, Malta

    Valletta makes a powerful first impression, its honey-coloured walls rising above Grand Harbour. Founded by the Knights of St John in 1566, Malta’s compact capital rewards exploration on foot. Enter St John’s Co-Cathedral for Caravaggio’s monumental paintings, then follow Republic Street to cafés, palaces and the Upper Barrakka Gardens. From the terraces, watch ferries cross the harbour and look towards the Three Cities. Allow time for steep lanes and quiet side streets.

  19. Day 23

    Souda-Chania, Greece

    Souda Bay places you within easy reach of Chania, one of Crete’s most compelling historic towns. A short drive leads to Chania’s Venetian harbour, with its lighthouse, waterfront cafés and narrow lanes. On the Akrotiri peninsula, monasteries and coastal views share the landscape with the Allied war cemetery overlooking Souda Bay. Make time for Cretan cooking, distinguished by fine olive oil, local cheeses and wild herbs.

  20. Day 24

    Kusadasi, Turkey

    Kuşadası puts the Aegean within reach, with a lively waterfront and one of Turkey’s most celebrated ancient cities nearby. Ephesus lies about 20 kilometres inland, where marble avenues lead to the Library of Celsus and Great Theatre. Back in town, browse the bazaar, then follow the causeway to Pigeon Island and its historic fortress. The harbour-facing promenade offers an easy place to linger over the Aegean light.

  21. Day 25

    Piraeus-Athens, Greece

    Piraeus is Athens’ working harbour, not a resort port—and that is its appeal. From here, the capital’s ancient landmarks are within reach, while the waterfront keeps its own busy, distinctly Greek character. Visit the Archaeological Museum of Piraeus, then linger over grilled fish in Mikrolimano, a small harbour lined with tavernas. Metro connections make central Athens straightforward. Or stay near the water and watch ferries depart for the islands.

Crystal Serenity Cruises

Published August 13, 2026
Last updated October 3, 2026
Author: J. Richard


Cruise Disclosure

Good to know: Prices are quoted per person based on double occupancy and include all applicable taxes and fees. Availability and prices can change quickly, so please continue through the booking process to confirm the latest availability and pricing before you pay.

We work hard to make sure everything on this website is accurate and up to date. However, some information may be incomplete or inaccurate, including details supplied by third parties or otherwise outside our control, and we cannot be held responsible for such errors. We work with 41 cruise line operators, that are providing cruises on 585 ships visiting 1,731 ports across 7,194 unique cruises, creating 13,822 itineraries. This is a great deal of data to continually update daily from our suppliers. If a pricing error, misrepresentation, or omission occurs, we reserve the right to adjust the pricing, correct the information, or cancel or decline any booking made in error, with notice to you. Thank you for your understanding!