Spain Cruise from Barcelona to Istanbul — 21 Days

20 nights · Spain · Departs Barcelona (Spain) · Visiting Sete, Marseille, Monte Carlo, Livorno, Civitavecchia-Rome, Sorrento, Siracusa, Santorini Island, Kusadasi, Piraeus-Athens, Milos Island, Rhodes Island, Marmaris, Izmir, Dikili, Bozcaada Island, Canakkale, Istanbul · Aboard Oceania Cruises on the Oceania Marina

Oceania Cruises logo
Cruise lineOceania Cruises
ShipOceania Marina
Duration20 nights
Port calls19
Departures1 sailings
From fare$6,499 per person
Year built2011
Guests1447
Cabins629
Crew800
Length251 m
Beam32 m
Cruising speed20.0 kn
  1. Day 1

    Barcelona, Spain

    Barcelona is a Mediterranean port city built on Roman foundations, with Gothic lanes and striking modernist architecture. La Rambla runs from Plaça de Catalunya towards the waterfront and the old town. Gaudí’s Sagrada Família and Park Güell show the city at its most distinctive. Set aside time for a market lunch and a walk through El Born, where medieval streets meet lively cafés. Barcelona’s beaches offer a welcome pause between visits.

  2. Day 2

    Sete, France

    Sète is France’s working Mediterranean port, set between the sea and the vast Étang de Thau. Canals cross the centre, alongside fishing boats, cafés and a covered market. Ride or walk up Mont Saint-Clair for broad views across the harbour, lagoons and coast. Sample oysters from nearby Bouzigues or choose the day’s catch at a port-side restaurant. Museums honour poet Paul Valéry and singer Georges Brassens, both born here, adding cultural depth to this lively port.

  3. Day 3

    Marseille, France

    Marseille is France’s oldest city, founded by Greek settlers around 600 BC, and it still faces the Mediterranean with confidence. Begin at the Vieux-Port, where fishing boats share the waterfront with cafés and ferries bound for nearby islands. Climb to Notre-Dame de la Garde for sweeping views, or explore Le Panier’s narrow lanes and lively squares. The Calanques’ limestone coves lie beyond the city; local markets bring Provençal flavors closer.

  4. Day 4

    Monte Carlo, Monaco

    Monte Carlo makes a striking first impression, with superyachts in Port Hercule and the Alps rising behind the coast. A short walk leads to Casino Square, where Belle Époque architecture frames the famous casino and designer boutiques. For a quieter contrast, climb to Monaco-Ville for the Prince’s Palace, cathedral and views across the harbor. The principality is compact and easy to explore on foot, though its steep streets reward comfortable shoes.

  5. Day 5

    Livorno, Italy

    Livorno rewards those who look beyond the cruise terminal. Its canals, built in the style of Venice, wind through historic Venezia Nuova. The seafront promenade leads to Terrazza Mascagni, where black-and-white paving frames the sea. At Mercato Centrale, locals shop beneath a vast iron-and-glass roof. Try cacciucco, the city’s rich fish stew. Florence and Pisa are within reach, but Livorno merits time of its own.

  6. Day 6

    Civitavecchia-Rome, Italy

    Your ship docks at Civitavecchia, Rome’s seaport, about 50 miles northwest of the capital. Rome’s great monuments are within reach, but the port town rewards a closer look. Walk the waterfront to Forte Michelangelo, a 16th-century fortress begun under Pope Julius II; explore the old streets and market. Prefer a quieter day? The town’s seafront and nearby beaches offer an easy change of pace. Choose Rome for art and antiquity, or Civitavecchia for coastal life beyond the terminal.

  7. Day 7

    Sorrento, Italy

    Sorrento rises above the Bay of Naples, facing Mount Vesuvius across water busy with ferries. From here, ferries connect with Capri, while the town rewards a slower day among old lanes, churches, and sea-view terraces. Follow the scent of citrus to shops selling Sorrento lemons, locally made limoncello, and finely crafted marquetry. Then pause over lunch: the region’s seafood and Campanian produce are best enjoyed without hurry.

  8. Day 8

    Siracusa, Italy

    Siracusa rewards visitors who look beyond its handsome waterfront. On Ortigia, the old island heart, Greek temples, Baroque palaces and lively markets sit within an easy walk. Across the channel, Neapolis Archaeological Park preserves a Greek theatre, Roman amphitheatre and the famed Ear of Dionysius. Pause for granita or fresh seafood, then watch the light soften over the Ionian Sea.

  9. Day 10

    Santorini Island, Greece

    Few Greek islands make an entrance like Santorini, where whitewashed villages crown a volcanic caldera above the Aegean. Most cruise ships anchor offshore, and tenders land at the old port below Fira. Ride the cable car, or climb the steps, to reach the island’s capital and its celebrated views. Beyond Fira, Oia’s blue domes, the archaeological site of Akrotiri, and volcanic wines reward a longer day ashore.

  10. Day 11

    Kusadasi, Turkey

    Kuşadası puts the Aegean within reach, with a lively waterfront and one of Turkey’s most celebrated ancient cities nearby. Ephesus lies about 20 kilometres inland, where marble avenues lead to the Library of Celsus and Great Theatre. Back in town, browse the bazaar, then follow the causeway to Pigeon Island and its historic fortress. The harbour-facing promenade offers an easy place to linger over the Aegean light.

  11. Day 13

    Piraeus-Athens, Greece

    Piraeus is Athens’ working harbour, not a resort port—and that is its appeal. From here, the capital’s ancient landmarks are within reach, while the waterfront keeps its own busy, distinctly Greek character. Visit the Archaeological Museum of Piraeus, then linger over grilled fish in Mikrolimano, a small harbour lined with tavernas. Metro connections make central Athens straightforward. Or stay near the water and watch ferries depart for the islands.

  12. Day 14

    Milos Island, Greece

    Arrive at Adamas, Milos’s sheltered ferry port, and you step onto an island shaped by fire and sea. Its volcanic geology has carved pale cliffs, sea caves, and beaches across the coast. Visit Sarakiniko’s sculpted white rock, then climb to Plaka for island-wide views and a quiet evening. At Tripiti, visit the early Christian catacombs and ancient theater, near where the Venus de Milo was found in 1820.

  13. Day 15

    Rhodes Island, Greece

    Rhodes pairs a fortified medieval capital with a sunlit Aegean coast. The UNESCO-listed Old Town stands just beyond the harbour, enclosed by formidable walls built by the Knights of St John. Walk its cobbled lanes to the Palace of the Grand Master, then pause over coffee in a shaded square. Beyond the city, beaches and whitewashed Lindos reward a longer outing; an ancient acropolis crowns the bay.

  14. Day 16

    Marmaris, Turkey

    Marmaris makes a striking first impression, with a yacht-filled harbor set beneath pine-clad mountains. From the quayside, lanes climb toward the 16th-century castle, whose museum and ramparts overlook the bay. The old town rewards a slow wander, while the covered bazaar offers Turkish textiles, ceramics, and spices. Beyond town, boat excursions reach sheltered coves and clear water; inland, the pine-fringed landscape invites a change of pace.

  15. Day 17

    Izmir, Turkey

    İzmir brings the Aegean within easy reach of a lively, modern Turkish city. Kordon’s waterfront promenade, cafés and ferries set an easy pace. Nearby, Kemeraltı Bazaar’s lanes reveal mosques, courtyards and centuries of trade. At the Agora of ancient Smyrna, Roman columns rise amid the city’s everyday bustle. İzmir also makes a practical gateway to Ephesus, one of the eastern Mediterranean’s most remarkable archaeological sites.

  16. Day 18

    Dikili, Turkey

    Dikili brings you to Turkey’s quieter Aegean shore, where pine-fringed hills meet clear water and a relaxed harbour town. Its greatest prize lies inland: Bergama, ancient Pergamon, about 30 kilometres away. Explore the Acropolis, the remains of a celebrated library, and the Asclepieion, once a major healing sanctuary. Back in Dikili, stroll the waterfront, swim at a nearby beach, or linger over fresh seafood before returning aboard.

  17. Day 19

    Bozcaada Island, Turkey

    Bozcaada lies in the northern Aegean, a short ferry ride from Geyikli on Turkey’s Çanakkale coast. Its harbor is watched by a castle, rebuilt under Ottoman rule and visible as ferries approach. Beyond the waterfront, lanes pass stone houses, cafés and churches that reflect the island’s Greek and Turkish past. Vineyards cover the inland slopes, while Ayazma Beach offers a swim in clear Aegean water.

  18. Day 20

    Canakkale, Turkey

    Çanakkale stands on the Asian shore of the Dardanelles, where Europe and Asia face each other across a busy strait. Its waterfront cafés, ferry traffic and Ottoman-era Çimenlik Castle offer a direct introduction to the city’s maritime past. Across the water, Gallipoli’s battlefields and memorials recall the 1915 campaign, while ancient Troy lies about 30 kilometres south. Both make compelling excursions, but leave time to walk the promenade and watch ferries cross the strait.

  19. Day 21

    Istanbul, Turkey

    Istanbul makes a compelling first impression: minarets rise above the Bosphorus, while ferries cross between Europe and Asia. On the historic peninsula, Hagia Sophia, the Blue Mosque and Topkapi Palace place centuries of empire within walking distance. Istanbul rewards curiosity beyond its landmarks. Browse the Grand Bazaar, linger over Turkish coffee, then take a ferry to the Asian shore. Allow time for traffic and queues; the city’s scale is part of the experience.

Oceania Marina Cruises

Published September 18, 2026
Last updated October 3, 2026
Author: J. Richard


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