Florida Cruise from Miami to San Francisco — 17 Days

16 nights · Florida · Departs Miami (USA) · Visiting Ocho Rios, Cartagena Colombia, Panama Canal, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Francisco · Aboard Regent Seven Seas Cruises on the Seven Seas Splendor

Regent Seven Seas Cruises logo
Cruise lineRegent Seven Seas Cruises
ShipSeven Seas Splendor
Duration16 nights
Port calls9
Departures1 sailings
From fare$26,398 per person
Year built2021
Guests829
Cabins375
Crew542
Length223 m
Beam32 m
Cruising speed22.0 kn
  1. Day 1

    Miami, USA

    Miami rewards travelers who look beyond its cruise terminals. South Beach pairs pastel Art Deco hotels with Ocean Drive; Little Havana serves Cuban coffee and music along Calle Ocho. The Pérez Art Museum Miami and nearby Design District reveal the city’s creative ambition. For a change of pace, Biscayne Bay and the Everglades place vivid natural landscapes within reach.

  2. Day 3

    Ocho Rios, Jamaica

    Ocho Rios puts Jamaica’s north coast within easy reach, where rainforest, rivers and the Caribbean meet. At Dunn’s River Falls, tiered limestone steps carry cool water toward the sea; visitors can climb with a guide. Explore Fern Gully, a shaded road winding through lush vegetation. Or settle beside the sea for jerk chicken and a view of the blue horizon.

  3. Day 5

    Cartagena Colombia, Colombia

    A short ride from Cartagena’s cruise port brings you to its UNESCO-listed historic centre and handsome colonial streets. Inside the old walls, flower-draped balconies, shaded plazas and broad stone lanes lead to cafés, churches and lively markets. Visit Castillo San Felipe de Barajas, the great fortress built to defend the harbor, then explore colorful Getsemaní. Come early, before the midday heat settles over the plazas, and save time for a cool drink beside the Caribbean.

  4. Day 6

    Panama Canal, Panama

    Few journeys change your sense of scale like a passage through the Panama Canal. This 50-mile waterway links the Atlantic and Pacific, lifting ships through locks and across Gatun Lake. Watch the gates close, water rise, and a vast vessel move within inches of concrete walls. On deck, the engineering is the spectacle; beyond it, rainforest edges the route. Bring binoculars, and stay outside for the crossing.

  5. Day 8

    Puntarenas

    Step ashore in Puntarenas, Costa Rica’s long, narrow port city on the Pacific coast. From here, rainforest reserves, coffee country and the Nicoya Peninsula lie within reach. Walk the waterfront promenade for seafood and views across the Gulf of Nicoya. Or head inland to Monteverde’s cloud forest. Plan one excursion and allow time for the road; Puntarenas is best enjoyed at an unhurried pace.

  6. Day 10

    Puerto Quetzal, Guatemala

    Puerto Quetzal is Guatemala’s Pacific gateway, a working port backed by volcanic highlands. Most visitors head inland to Antigua, where cobbled streets, pastel façades and church ruins preserve a distinctive colonial setting. The drive takes roughly 90 minutes, depending on traffic. Closer to the coast, excursions visit fishing villages and black-sand beaches. Choose Antigua for architecture and history, or stay coastal for a closer look at everyday life in Guatemala.

  7. Day 13

    Puerto Vallarta, Mexico

    Puerto Vallarta sits between the Sierra Madre mountains and Banderas Bay. That setting brings jungle-clad slopes, broad beaches and memorable Pacific views. Begin in the historic center, where cobbled streets lead to the landmark Church of Our Lady of Guadalupe. Follow the Malecón, a seafront promenade lined with sculptures, cafés and galleries. For a taste of the coast, settle in for fresh seafood and watch the bay.

  8. Day 14

    Cabo San Lucas, Mexico

    Cabo San Lucas sits at the tip of Baja California Sur, where the Pacific meets the Sea of Cortez. Cruise ships anchor offshore, and tenders bring you to a lively marina lined with cafés, fishing boats and shops. From the marina, water taxis reach El Arco, the sculpted granite landmark at Land’s End. Beyond it, beaches and desert trails reveal a quieter side of Cabo. Choose a boat trip, fresh seafood or a day in the sun.

  9. Day 17

    San Francisco, USA

    San Francisco rewards visitors who look beyond the postcard. Ride a cable car over steep streets, then explore Chinatown, North Beach, or the Ferry Building’s stalls. The Golden Gate Bridge frames the bay, while Alcatraz offers a stark look at the city’s past. For a quieter hour, walk the waterfront or cross to Sausalito by ferry. Few ports make a day ashore feel so varied—and so distinctly Californian.

Seven Seas Splendor Cruises

Published August 11, 2026
Last updated October 3, 2026
Author: J. Richard


Cruise Disclosure

Good to know: Prices are quoted per person based on double occupancy and include all applicable taxes and fees. Availability and prices can change quickly, so please continue through the booking process to confirm the latest availability and pricing before you pay.

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