Florida Cruise from Miami to Los Angeles — 17 Days

16 nights · Florida · Departs Miami (USA) · Visiting Grand Cayman Island, Cartagena Colombia, Panama Canal, Puntarenas, Puerto Quetzal, Acapulco, Cabo San Lucas, Ensenada, Los Angeles · Aboard Regent Seven Seas Cruises on the Seven Seas Prestige

Regent Seven Seas Cruises logo
Cruise lineRegent Seven Seas Cruises
ShipSeven Seas Prestige
Duration16 nights
Port calls10
Departures1 sailings
From fare$30,798 per person
Year built2026
Guests822
Cabins411
Crew630
Length257 m
Beam44 m
Cruising speed19.0 kn
  1. Day 1

    Miami, USA

    Miami rewards travelers who look beyond its cruise terminals. South Beach pairs pastel Art Deco hotels with Ocean Drive; Little Havana serves Cuban coffee and music along Calle Ocho. The Pérez Art Museum Miami and nearby Design District reveal the city’s creative ambition. For a change of pace, Biscayne Bay and the Everglades place vivid natural landscapes within reach.

  2. Day 3

    Grand Cayman Island

    Grand Cayman pairs clear water with an easy blend of beach and town. Ships anchor offshore; tenders land in George Town, near duty-free shops, cafés and the Cayman Islands National Museum. Boat trips reach Stingray City, where visitors can encounter southern stingrays in shallow water. Beyond town, Seven Mile Beach is known for pale sand and turquoise water. Choose a beach transfer, an island tour or time in town; Grand Cayman makes a relaxed, rewarding call.

  3. Day 5

    Cartagena Colombia, Colombia

    A short ride from Cartagena’s cruise port brings you to its UNESCO-listed historic centre and handsome colonial streets. Inside the old walls, flower-draped balconies, shaded plazas and broad stone lanes lead to cafés, churches and lively markets. Visit Castillo San Felipe de Barajas, the great fortress built to defend the harbor, then explore colorful Getsemaní. Come early, before the midday heat settles over the plazas, and save time for a cool drink beside the Caribbean.

  4. Day 6

    Panama Canal, Panama

    Few journeys change your sense of scale like a passage through the Panama Canal. This 50-mile waterway links the Atlantic and Pacific, lifting ships through locks and across Gatun Lake. Watch the gates close, water rise, and a vast vessel move within inches of concrete walls. On deck, the engineering is the spectacle; beyond it, rainforest edges the route. Bring binoculars, and stay outside for the crossing.

  5. Day 8

    Puntarenas

    Step ashore in Puntarenas, Costa Rica’s long, narrow port city on the Pacific coast. From here, rainforest reserves, coffee country and the Nicoya Peninsula lie within reach. Walk the waterfront promenade for seafood and views across the Gulf of Nicoya. Or head inland to Monteverde’s cloud forest. Plan one excursion and allow time for the road; Puntarenas is best enjoyed at an unhurried pace.

  6. Day 10

    Puerto Quetzal, Guatemala

    Puerto Quetzal is Guatemala’s Pacific gateway, a working port backed by volcanic highlands. Most visitors head inland to Antigua, where cobbled streets, pastel façades and church ruins preserve a distinctive colonial setting. The drive takes roughly 90 minutes, depending on traffic. Closer to the coast, excursions visit fishing villages and black-sand beaches. Choose Antigua for architecture and history, or stay coastal for a closer look at everyday life in Guatemala.

  7. Day 12

    Acapulco, Mexico

    Acapulco’s broad bay curves between green headlands, giving this Pacific port its unmistakable setting. Visit Fort of San Diego to explore exhibits on the region’s maritime history. At La Quebrada, divers plunge from cliffs into the sea, a tradition watched from terraces above. Beyond the spectacle, beaches, seafood restaurants, and waterfront promenades make an easy day ashore.

  8. Day 14

    Cabo San Lucas, Mexico

    Cabo San Lucas sits at the tip of Baja California Sur, where the Pacific meets the Sea of Cortez. Cruise ships anchor offshore, and tenders bring you to a lively marina lined with cafés, fishing boats and shops. From the marina, water taxis reach El Arco, the sculpted granite landmark at Land’s End. Beyond it, beaches and desert trails reveal a quieter side of Cabo. Choose a boat trip, fresh seafood or a day in the sun.

  9. Day 16

    Ensenada, Mexico

    Ensenada is Baja California’s lively Pacific port, where fresh seafood and celebrated wine country meet. Downtown cafés, market stalls and the history museum are close to the waterfront. Order fish tacos, a local specialty, or travel inland to Valle de Guadalupe, Mexico’s leading wine region. Taste among the vineyards, or head south to La Bufadora, a marine blowhole famed for its spray. Ensenada rewards a day planned around one good meal, one glass and the coast.

  10. Day 17

    Los Angeles, USA

    San Pedro is Los Angeles’s maritime gateway, home to one of the world’s busiest container ports. See the Battleship Iowa, explore San Pedro’s waterfront, or visit the Korean Bell of Friendship for coastal views. Downtown’s museums and architecture sit roughly 20 miles north, while Hollywood and the beaches call for longer excursions. Choose a district and give it time; this vast city is best explored with a clear plan.

Seven Seas Prestige Cruises

Published August 6, 2026
Last updated October 3, 2026
Author: J. Richard


Cruise Disclosure

Good to know: Prices are quoted per person based on double occupancy and include all applicable taxes and fees. Availability and prices can change quickly, so please continue through the booking process to confirm the latest availability and pricing before you pay.

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