Cruises to Panama Canal

Discover Panama Canal, starting from Colón, Panama

Panama Canal Cruises

Sailings that call at Panama Canal, earliest departure first.

346 Sailings Found
Fort Lauderdale, United States

17 Days One-Way from Fort Lauderdale to Los Angeles

Sapphire Princess

Departs
November 6th 2026
Duration
16 nights
From
$1,599
per person, double occupancy
Ports of call: +3 more ports
Fort Lauderdale, United States

18 Days One-Way from Fort Lauderdale to Valparaiso-Santiago

Viking Octantis

Departs
November 6th 2026
Duration
17 nights
From
$9,295
per person, double occupancy
Ports of call: +2 more ports
Fort Lauderdale, United States

41 Days One-Way from Fort Lauderdale to Ushuaia

Viking Octantis

Departs
November 6th 2026
Duration
40 nights
Ports of call: +10 more ports

Why Book With Waterways Cruise?

Four decades of expertise, one dedicated advisor, and every detail handled, from your front door to the gangway and back.

Personal Service

Cruise Concierge

A dedicated advisor who learns your name, your travel style and your preferences, then stays with you from the first conversation to the day you return home. Not a call center. Never a stranger.

Tailor-Made

100% Custom‑Built

No cookie-cutter packages. Flights, hotels, transfers and shore days are designed from scratch around how you actually like to travel, then refined until the trip feels like yours.

Expertise

40+ Years in Travel

Founded by J. Richard, a four-decade veteran of the travel industry, and focused solely on premium river and ocean cruising. Decades of ship and itinerary knowledge go into every recommendation.

Security

Book With Total Confidence

A travel agency that is a proud member of Signature Travel Network, CLIA, ASTA and IATA.

Miami, United States

13 Days Miami, USA Round Trip

Norwegian Sun

Departs
November 6th 2026
Duration
12 nights
From
$1,769
per person, double occupancy
Ports of call: +3 more ports
Colon, Panama

8 Days One-Way from Colon to Puntarenas

Le Bellot

Departs
November 7th 2026
Duration
7 nights
From
$5,880
per person, double occupancy
Ports of call:
Colon, Panama

8 Days Colon, Panama Round Trip

Grandeur Of The Seas

Departs
November 7th 2026
Duration
7 nights
From
$643
per person, double occupancy
Ports of call:
Cartagena Colombia, Colombia

7 Days One-Way from Cartagena Colombia to Colon

Grandeur Of The Seas

Departs
November 8th 2026
Duration
6 nights
From
$903
per person, double occupancy
Ports of call:
Fort Lauderdale, United States

13 Days Fort Lauderdale, USA Round Trip

ms Nieuw Amsterdam

Departs
November 8th 2026
Duration
12 nights
From
$1,319
per person, double occupancy
Ports of call: +2 more ports
Fort Lauderdale, United States

22 Days Fort Lauderdale, USA Round Trip

ms Nieuw Amsterdam

Departs
November 8th 2026
Duration
21 nights
From
$1,939
per person, double occupancy
Ports of call: +4 more ports
Colon, Panama

19 Days One-Way from Colon to Valparaiso-Santiago

Hanseatic Inspiration

Departs
November 9th 2026
Duration
18 nights
From
$31,240
per person, double occupancy
Ports of call: +2 more ports
Lisbon, Portugal

26 Days One-Way from Lisbon to Colon

Wind Star

Departs
November 10th 2026
Duration
25 nights
Ports of call: +4 more ports
Fort Lauderdale, United States

13 Days Fort Lauderdale, USA Round Trip

Caribbean Princess

Departs
November 11th 2026
Duration
12 nights
From
$934
per person, double occupancy
Ports of call: +1 more port
San Juan, Puerto Rico

8 Days One-Way from San Juan to Panama City

Ritz-Carlton Evrima

Departs
November 12th 2026
Duration
7 nights
From
$8,200
per person, double occupancy
Ports of call:
Miami, United States

22 Days Miami, USA Round Trip

MSC Poesia

Departs
November 12th 2026
Duration
21 nights
From
$1,819
per person, double occupancy
Ports of call: +5 more ports
Panama City, Panama

11 Days One-Way from Panama City to Fort Lauderdale

Viking Mars

Departs
November 13th 2026
Duration
10 nights
From
$3,999
per person, double occupancy
Ports of call: +2 more ports
Puntarenas, Costa Rica

8 Days One-Way from Puntarenas to Colon

Le Bellot

Departs
November 14th 2026
Duration
7 nights
From
$5,880
per person, double occupancy
Ports of call:
Panama City, Panama

15 Days One-Way from Panama City to St Johns Antigua

Royal Clipper

Departs
November 14th 2026
Duration
14 nights
From
$4,450
per person, double occupancy
Ports of call: +6 more ports
Colon, Panama

11 Days Colon, Panama Round Trip

Grandeur Of The Seas

Departs
November 14th 2026
Duration
10 nights
From
$1,208
per person, double occupancy
Ports of call: